Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case
Apocrine adenocarcinoma of the eyelid with aggressive biological behavior: Report of a case
复制标题
具有侵袭性生物学行为的眼睑顶浆腺癌：一例报告
DOI：
--
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Kazuo Noda
中科院分区：
文献类型：
--
作者：
M. Shintaku;K. Tsuta;H. Yoshida;A. Tsubura;Y. Nakashima;Kazuo Noda
报告1例眼睑大汗腺腺癌，表现出异常的侵袭性生物学行为。患者为一名57岁男性，主诉左眼不适和过度流泪。在上眼睑的内眦处发现了一个2.5 cm的皮下肿瘤，在泪阜中发现了一个皱襞样结膜下扩散。在初次出现时，已经存在眼外肌浸润和颈淋巴结及骨转移。组织学上，肿瘤表现为低分化腺癌的特征，多角形肿瘤细胞具有大的深染核，核仁突出，胞浆丰富嗜酸性。偶见导管状结构形成。使用单克隆抗体GCDFP-15和B72.3通过免疫组织化学证实肿瘤细胞向顶泌腺分化。本文对肿瘤的组织发生和病理鉴别诊断作了简要讨论，认为肿瘤起源于眼睑Moll腺。这个病例强调了眼部顶浆腺癌具有潜在的侵袭性生物学行为，包括远处转移。
A case of apocrine adenocarcinoma of the eyelid that showed unusually aggressive biological behavior is reported. The patient was a 57‐year‐old man who complained of discomfort and excessive lacrimation of the left eye. A subcutaneous tumor measuring 2.5 cm was found at the medial canthus of the upper eyelid, and a plica‐like subconjunctival spread was noted in the lacrimal caruncle. Invasion into the extraocular muscles and metastasis to the cervical lymph nodes and bone were already present at the time of initial presentation. Histopathologically, the tumor showed features of poorly differentiated adenocarcinoma, and polygonal tumor cells had large, hyperchromatic nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. The formation of ductal structures was found occasionally. The differentiation of the tumor cells towards the apocrine gland was corroborated by immunohistochemistry using monoclonal antibodies GCDFP‐15 and B72.3. The histogenesis and pathological differential diagnosis are discussed briefly, and the tumor was considered to have originated in the Moll’s gland in the eyelid. This case emphasizes that apocrine adenocarcinomas of the ocular region have the potential for aggressive biological behavior, including distant metastasis.
乳腺总囊性疾病液体蛋白 (GCDFP-15) 的免疫组织化学。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Mazoujian,G;Pinkus,GS;Davis,S;HaagensenJr,DE
通讯作者：
HaagensenJr,DE