Reversal of cathepsin D routing modulation in MCF-7 breast cancer cells expressing antisense insulin-like growth factor II (IGF-II).
Reversal of cathepsin D routing modulation in MCF-7 breast cancer cells expressing antisense insulin-like growth factor II (IGF-II).
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表达反义胰岛素样生长因子 II (IGF-II) 的 MCF-7 乳腺癌细胞中组织蛋白酶 D 路由调节的逆转。
DOI：
10.1055/s-2007-978712
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Asmerom,Y
中科院分区：
文献类型：
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作者：
DeLeon,DD;Issa,N;Nainani,S;Asmerom,Y
甘露糖6-磷酸（M6 P）受体将溶酶体酶转运至溶酶体[11.由于该受体也与IGF-II结合，因此被称为IGF-II/M6 P受体。虽然溶酶体酶和IGF-II的结合位点不同，但在哺乳动物IGF-II/M6 P受体中观察到IGF-II和溶酶体酶之间结合的相互抑制[2，31]。尽管大多数IGF-II/M6 P受体存在于细胞内（其功能是将新合成的溶酶体酶引导至溶酶体），但一些受体循环往返于质膜（其中细胞外溶酶体酶和IGF-II与受体结合并内化）。
The mannose 6-phosphate (M6P) receptor transports lysosomal enzymes to lysosomes [11. Because this receptor also binds IGF-ll, it is known as the IGF-II/M6P receptor. Although the binding sites for lysosomal enzymes and IGF-ll are distinct, reciprocal inhibition of binding between IGF-Il and lysosomal enzymes has been observed in the mammalian IGF-ll/M6P re-ceptor [2, 31. Although most of the IGF-Il/M6P receptor is found intracellularly (where it functions to direct newly synthesized lysosomal enzymes to lysosomes), some receptors cycle to and from the plasma membrane (where extracellular lysosomal enzymes and IGF-ll bind to the receptor and are internalized)