Fas expression and apoptosis in human B cells.
Fas expression and apoptosis in human B cells.
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人 B 细胞中的 Fas 表达和凋亡。
DOI：
10.1007/bf02918252
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发表时间：
1996
影响因子：
4.4
通讯作者：
Friedman,SM
中科院分区：
文献类型：
--
作者：
Schattner,E;Friedman,SM
B细胞的凋亡机制在减少异常的B细胞增殖方面至关重要，例如在自身免疫性疾病和B细胞恶性肿瘤中出现的B细胞增殖。在过去的二十年里，人们对CD4+辅助T细胞和B淋巴细胞的生理相互作用进行了广泛的研究。虽然CD4+T细胞主要被认为是为B细胞分化为活性免疫球蛋白分泌细胞提供积极的共刺激信号，但最近的研究表明，CD4+T细胞在下调体液免疫反应方面起着至关重要的作用。在CD40配体(CD40L)负载的CD4+T细胞与表达CD40的生发中心B细胞之间的同源相互作用过程中，CD40结扎导致B细胞表面Fas表达增强。与CD40L一样，Fas配体在活化的CD4+Th1细胞上表达，当与B细胞表面的Fas受体结合时，启动该细胞的凋亡信号。因此，CD4+T细胞通过首先诱导Fas表达，然后通过Fas配体激发死亡信号来限制自体生发中心B细胞的生长。在这项工作中，我们将在影响正常和恶性B细胞凋亡的其他因素的背景下，考虑这些关于CD4+T细胞诱导的、Fas介导的B细胞死亡的观察。
Mechanisms of B cell apoptosis are critical in reducing aberrant B cell proliferations such as those that arise in autoimmune disease and in B cell malignancies. The physiologic interaction of CD4+ helper T cells and B lymphocytes has been extensively studied over the past two decades. Although CD4+ T cells are considered primarily to offer positive costimulatory signals for B cell differentiation into active immunoglobulin-secreting cells, recent studies have shown that CD4+ T cells are crucial in downregulating the humoral immune response. In the course of cognate interaction between CD40 ligand (CD40L)-bearing CD4+ T cells and CD40-expressing germinal center B cells, CD40 ligation results in augmented Fas expression at the B cell surface. Like CD40L, Fas ligand is expressed on activated CD4+ Th1 cells and when bound to Fas receptor on the B cell surface, initiates an apoptotic signal in that cell. Thus, CD4+ T cells limit the growth of autologous germinal center B cells by first inducing Fas expression and then instigating a death signal via Fas ligand. In this work, we will consider these observations about CD4+ T-cell-induced, Fas-mediated B cell death in the context of other factors that affect apoptosis in B cells, normal and malignant.