Three new azaphilones produced by a marine fish-derived chaetomium globosum
Three new azaphilones produced by a marine fish-derived chaetomium globosum
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DOI：
10.1038/ja.2012.40
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发表时间：
2012-05
期刊：
影响因子：
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通讯作者：
Takeshi Yamada;Masaaki Jinno;Takashi Kikuchi;T. Kajimoto;A. Numata;R. Tanaka
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文献类型：
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作者：
Takeshi Yamada;Masaaki Jinno;Takashi Kikuchi;T. Kajimoto;A. Numata;R. Tanaka
从一株来源于海鱼Mugil cephalus的球毛壳菌（Chaetomium globosum）中分离得到3个新的代谢产物，即毛球壳菌素S、脱氯毛球壳菌素A和脱氯毛球壳菌素D，并利用1D和2D NMR技术及化学转化等手段确定了它们的绝对立体结构。特别地，毛霉菌素T和U是迄今为止从该真菌菌株分离的azaphilones中第一个不含氯原子的化合物。此外，这些化合物适度抑制培养的P388、HL-60、L1210和KB细胞系的生长。
Three new metabolites, chaetomugilin S, dechloro-chaetomugilin A and dechloro-chaetomugilin D, were isolated from a strain of Chaetomium globosum originally obtained from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated based on the basis of spectroscopic analyses, including 1D and 2D NMR techniques and some chemical transformations. Particularly, chaetomugilins T and U are the first compouds without a chlorine atom in azaphilones isolated from this fungal strain, to date. In addition, these compounds moderately inhibited the growth of cultured P388, HL-60, L1210 and KB cell lines.