Sequence-specific binding of single-stranded RNA: is there a code for recognition?
Sequence-specific binding of single-stranded RNA: is there a code for recognition?
复制标题
DOI：
10.1093/nar/gkl620
复制
发表时间：
2006
影响因子：
14.9
通讯作者：
Allain FH
中科院分区：
文献类型：
--
作者：
Auweter SD;Oberstrass FC;Allain FH
根据蛋白质的氨基酸序列或结构预测其结合的RNA序列，将为设计具有所需序列特异性的RNA结合物提供有用的工具。这种重新设计的RNA结合物在医学和基础研究应用中都有非凡的用途。此外，一个密码可以帮助预测rna结合蛋白的细胞功能，而这些功能尚未得到广泛的研究。本文对Pumilio同源结构域、含锌RNA结合物、hnRNP - K同源结构域和RNA识别基序进行了比较分析。在此基础上，提出了一套结合规则，提示这些结构域的RNA识别代码。此外，我们讨论了对RNA结合很重要的分子间相互作用，并总结了它们在提供亲和力和特异性方面的重要性。
A code predicting the RNA sequence that will be bound by a certain protein based on its amino acid sequence or its structure would provide a useful tool for the design of RNA binders with desired sequence-specificity. Such de novo designed RNA binders could be of extraordinary use in both medical and basic research applications. Furthermore, a code could help to predict the cellular functions of RNA-binding proteins that have not yet been extensively studied. A comparative analysis of Pumilio homology domains, zinc-containing RNA binders, hnRNP K homology domains and RNA recognition motifs is performed in this review. Based on this, a set of binding rules is proposed that hints towards a code for RNA recognition by these domains. Furthermore, we discuss the intermolecular interactions that are important for RNA binding and summarize their importance in providing affinity and specificity.
登录
查看更多内容
影响因子：
4.8
作者：
Enokizono, Y;Konishi, Y;Katahira, M
通讯作者：
Katahira, M
影响因子：
15
作者：
Biot, C;Buisine, E;Rooman, M
通讯作者：
Rooman, M
影响因子：
5.6
作者：
Deardorff, JA;Sachs, AB
通讯作者：
Sachs, AB
影响因子：
11.4
作者：
Allain, FHT;Howe, PWA;Varani, G
通讯作者：
Varani, G
影响因子：
5.7
作者：
Backe, PH;Messias, AC;Cusack, S
通讯作者：
Cusack, S