Assessment of regional variation in polypharmacy
Assessment of regional variation in polypharmacy
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DOI：
10.1002/pds.1921
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发表时间：
2010-04-01
影响因子：
2.6
通讯作者：
Petersson, Goran
中科院分区：
文献类型：
--
作者：
Hovstadius, Bo;Astrand, Bengt;Petersson, Goran
目的评估多药在人口中，强调regions.Methods我们研究了基于个人的数据，所有的处方药（DP）在3个月的研究期间，在瑞典2006年。作为多种药物的指标，使用了五种或五种以上（DP >= 5）不同的药物（物质）。分析中，我们使用了流行率的比较，多药治疗的流行率与不同的社会经济变量的相关性，和一个新的加权multipharmacy index.Results的多药治疗，DP >= 5，全国患病率为10.5%（地区间变异9.1-12.1%）。多种药物使用率的区域差异在≥ 90岁（45.6-59.1%）、80-89岁（46.1-53.4%）和70-79岁（33.1-38.0%）年龄组中最大。DP >= 10的过度多种药物的全国流行率为2.2%（区域间差异为1.9-2.6%）。在≥ 90岁（9.8-22.3%）、80-89岁（11.4-17.1%）和70-79岁（7.0-9.4%）的年龄组中，过度多种用药流行率的区域差异最大。我们发现一个相当强的正相关关系之间的多药和年龄组>= 70岁（r = 0.84男性和0.71女性）。新的加权multipharmacy指数表明，在内部分配的流行病的药物与multipharmacy. Conclusion个人的区域差异，我们的研究结果表明，观察到的区域差异的流行病的multipharmacy部分可以解释在瑞典的区域年龄分布。新的加权多药指数的使用表明，药物治疗的个人与多药的区域差异。版权所有（C）2010约翰威利父子有限公司
Purpose To assess polypharmacy in a population with emphasis on regions.Methods We studied the individual-based data of all dispensed prescription drugs (DP) during a 3-month study period in Sweden 2006. As an indicator of polypharmacy, five or more (DP >= 5) different drugs (substances) dispensed were applied. For analysis, we used comparisons of prevalence, correlation of prevalence of polypharmacy with different socioeconomic variables, and a novel weighted polypharmacy index.Results The national prevalence of polypharmacy, DP >= 5, was 10.5% (inter-regional variation 9.1-12.1%). The regional variation in the prevalence of polypharmacy was largest for the age groups >= 90 (45.6-59.1%), 80-89 (46.1-53.4%) and 70-79 years (33.1-38.0%). The national prevalence of excessive polypharmacy, DP >= 10, was 2.2% (inter-regional variation 1.9-2.6%). The regional variation in prevalence of excessive polypharmacy was largest for the age groups >= 90 (9.8-22.3%), 80-89 (11.4-17.1%) and 70-79 years (7.0-9.4%). We found a fairly strong positive correlation between polypharmacy and the age group >= 70 years (r = 0.84 for men and 0.71 for women). The novel weighted polypharmacy index indicated regional differences in the internal distribution of the prevalence of dispensed drugs for individuals with polypharmacy.Conclusion Our findings indicate that the observed regional differences in the prevalence of polypharmacy partly can be explained by the regional age distribution in Sweden. The use of the novel weighted polypharmacy index indicated regional differences in drug therapy for individuals with polypharmacy. Copyright (C) 2010 John Wiley & Sons, Ltd.