Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination
Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination
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DOI：
10.1167/iovs.07-1460
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发表时间：
2008-07-01
影响因子：
4.4
通讯作者：
Wolf, Sebastian
中科院分区：
文献类型：
--
作者：
Wolf-Schnurrbusch, Ute E. K.;Enzmann, Volker;Wolf, Sebastian
目的。目的 研究使用新型组合 OCT 扫描激光眼科 (SLO) 系统同时记录的高分辨率光学相干断层扫描 (OCT) 图像、眼底自发荧光 (FAF) 图案和红外图像中地理萎缩的出现情况。方法。在一项前瞻性横断面研究中，通过同步光谱 OCT-SLO（Spectralis HRA + OCT；德国海德堡海德堡工程公司）对年龄超过 50 岁、继发于干性年龄相关性黄斑变性 (ARMD) 的地图样萎缩的患者进行了评估。对表面正常区域、正常视网膜与地理性萎缩之间的交界区以及萎缩区域的视网膜层的完整性进行了分析。评估了外界膜、光感受器内节、外节和视网膜色素上皮的存在和完整性。结果。对年龄 51 至 92 岁的 52 名患者（28 名女性，24 名男性）的 52 只眼睛进行了检查。记录了视网膜层的改变，不仅在萎缩区，而且在地理性萎缩周围的交界区。视网膜层的崩解始于RPE和邻近的视网膜层，例如感光器内节、外节和外界膜。结论。新颖的成像方式将为 ARMD 发病机制提供进一步有价值的见解。了解形态变化的关键在于通过光谱 OCT 技术结合 FAF 等其他成像方式对视网膜层进行体内描绘。
PURPOSE. To investigate the appearance of geographic atrophy in high-resolution optical coherence tomography (OCT) images, the fundus autofluorescence (FAF) pattern, and infrared images simultaneously recorded with a novel combined OCT-scanning laser ophthalmology (SLO) system.METHODS. Patients aged over 50 years with geographic atrophy secondary to dry age-related macular degeneration (ARMD) were assessed in a prospective cross-sectional study by means of simultaneous spectral OCT-SLO (Spectralis HRA + OCT; Heidelberg Engineering, Heidelberg, Germany). The integrity of the retinal layers was analyzed in the apparently normal areas, the junctional zone between the normal retina and the geographic atrophy, and the atrophic area. The presence and integrity of the external limiting membrane, the photoreceptor inner segments, the outer segments, and the retinal pigment epithelium were assessed.RESULTS. Fifty-two eyes of 52 patients (28 women, 24 men) aged 51 to 92 years were examined. Retinal layer alterations were documented, not only in atrophic zones, but also in junctional zones surrounding the geographic atrophy. Disintegration of the retinal layers began in the RPE and adjacent retinal layers, such as the photoreceptor inner and outer segments and external limiting membrane.CONCLUSIONS. Novel imaging modalities will provide further valuable insight into ARMD pathogenesis. The key to understanding the morphologic change lies in in vivo depiction of retinal layers by spectral OCT technology in combination with other imaging modalities such as FAF.