Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles
Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles
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DOI：
10.1152/ajpcell.00483.2001
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发表时间：
2002-05-01
影响因子：
5.5
通讯作者：
Pavlath, GK
中科院分区：
文献类型：
--
作者：
Mitchell, PO;Mills, ST;Pavlath, GK
充足的肌肉质量对人体健康至关重要。调节成人骨骼肌维持和生长的分子途径知之甚少。钙调神经磷酸酶（CN）是参与肥大的关键信号分子。CN是否参与所有形式的肌肉生长或不同的肌肉是未知的。在这里，我们研究CN在调节比目鱼肌（慢）和跖肌（快）的肌肉大小和萎缩肌肉的生长维持的作用。CN抑制剂环孢菌素A（CsA）根据肌肉表型不同影响肌肉生长和维持。在这两种生长条件下，足底比比目鱼肌受到CsA更严重的影响。一周与2周CsA治疗表明，CN依赖性和CN独立的增长发生在萎缩的比目鱼肌，而跖肌的增长似乎是完全CN依赖。我们的研究结果表明，CN调节多种类型的肌肉生长，这取决于肌肉表型和肌纤维生长的阶段。CN途径的组分的差异表达发生，并且可能有助于肌肉之间的差异。
Adequate muscle mass is critical for human health. The molecular pathways regulating maintenance and growth of adult skeletal muscle are little understood. Calcineurin (CN) is implicated as a key signaling molecule in hypertrophy. Whether CN is involved in all forms of muscle growth or in different muscles is unknown. Here, we examine the role of CN in regulating maintenance of muscle size and growth of atrophied muscle in the soleus (slow) and plantaris (fast). The CN inhibitor cyclosporin A (CsA) differentially affects muscle growth and maintenance depending on muscle phenotype. The plantaris is more severely affected by CsA than the soleus in both growth conditions. One-week vs. 2-wk CsA treatment suggests that both CN-dependent and CN-independent growth occur in the atrophied soleus, whereas plantaris growth appears to be totally CN dependent. Our results suggest that CN regulates multiple types of muscle growth, depending both on muscle phenotype and stage of myofiber growth. Differential expression of components of the CN pathway occurs and may contribute to the differences between muscles.