Knee Images Digital Analysis (KlDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail
Knee Images Digital Analysis (KlDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail
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DOI：
10.1016/j.joca.2007.06.009
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发表时间：
2008-02-01
影响因子：
7
通讯作者：
Lafeber, F. P. J. G.
中科院分区：
文献类型：
--
作者：
Marijnissen, A. C. A.;Vincken, K. L.;Lafeber, F. P. J. G.
目的：骨性关节炎(OA)的影像特征，如关节间隙变窄、软骨下硬化、骨赘形成等，目前仍以X线片为金标准。然而，客观评估仍然很困难。本研究的目的是评价一种新的数字化分析标准膝关节X线片的方法。方法：按照Buckland-Wright的半屈曲法拍摄20个健康膝关节和55个CA膝关节的标准X线片。关节间隙宽度(JSW)、骨赘面积、软骨下骨密度、关节角度和胫骨隆起高度作为连续变量在标准PC上使用新开发的膝关节图像数字分析(KIDA)软件进行测量。两名观察员对射线照片进行了两次评估，每次都在两个不同的场合。观察者对射线照片的来源和他们以前的测量结果视而不见。根据Bland和Altman的说法，进行统计分析以比较观察者内部和之间的测量结果。计算KIDA数据与Kellgren&Lawrence(K&L)分级的相关性，并将健康膝关节和CA膝关节的数据进行比较。结果：关节滑脱、软骨下骨密度、骨赘、胫骨隆起和关节角度的测量在观察者内和观察者间的变化较小。KIDA参数与K&L分级呈显著正相关。结论：在标准X线片上，除了JSW测量外，骨赘形成和软骨下骨密度的客观评估是可能的。CA和健康人之间的测量差异表明，KIDA可以及时检测到变化，尽管对变化的敏感性必须在长期的后续研究中证明。(C)2007年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: Radiography is still the golden standard for imaging features of osteoarthritis (OA), such as joint space narrowing, subchondral sclerosis, and osteophyte formation. Objective assessment, however, remains difficult. The goal of the present study was to evaluate a novel digital method to analyse standard knee radiographs.Methods: Standardized radiographs of 20 healthy and 55 CA knees were taken in general practise according to the semi-flexed method by Buckland-Wright. Joint Space Width (JSW), osteophyte area, subchondral bone density, joint angle, and tibial eminence height were measured as continuous variables using newly developed Knee Images Digital Analysis (KIDA) software on a standard PC. Two observers evaluated the radiographs twice, each on two different occasions. The observers were blinded to the source of the radiographs and to their previous measurements. Statistical analysis to compare measurements within and between observers was performed according to Bland and Altman. Correlations between KIDA data and Kellgren & Lawrence (K&L) grade were calculated and data of healthy knees were compared to those of CA knees.Results: Intra- and inter-observer variations for measurement of JSW, subchondral bone density, osteophytes, tibial eminence, and joint angle were small. Significant correlations were found between KIDA parameters and K&L grade. Furthermore, significant differences were found between healthy and CA knees.Conclusion: In addition to JSW measurement, objective evaluation of osteophyte formation and subchondral bone density is possible on standard radiographs. The measured differences between CA and healthy individuals suggest that KIDA allows detection of changes in time, although sensitivity to change has to be demonstrated in long-term follow-up studies. (c) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.