RELIEF OF EXPERIMENTALLY INDUCED PRURITUS WITH A NOVEL EUTECTIC MIXTURE OF LOCAL-ANESTHETIC AGENTS
RELIEF OF EXPERIMENTALLY INDUCED PRURITUS WITH A NOVEL EUTECTIC MIXTURE OF LOCAL-ANESTHETIC AGENTS
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DOI：
10.1111/j.1365-2133.1988.tb03259.x
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发表时间：
1988-10-01
影响因子：
10.3
通讯作者：
CONNELLY, DM
中科院分区：
文献类型：
--
作者：
SHUTTLEWORTH, D;HILL, S;CONNELLY, DM
本文报告了局部麻醉药木洛昔和丙胺卡因的低共熔混合物（EMLA乳膏）对20名志愿者的止痒效果。这项研究分两部分进行。在第一部分中，通过双盲安慰剂对照方法评估EMLA对引起瘙痒所需的组胺阈值浓度的影响。第二部分采用单盲法观察EMLA对人工致痒剂牛磺酸和木瓜蛋白酶所致皮肤瘙痒的影响。一些受试者在安慰剂乳膏治疗后对组胺的敏感性降低，但所有受试者在EMLA治疗后对组胺的敏感性均显着降低。EMLA和安慰剂治疗之间的差异具有统计学意义。发现EMLA制剂对由牛饲料和木瓜蛋白酶引起的瘙痒有效，并且该效果也具有统计学显著性。因此，发现EMLA乳膏在减少实验诱导的瘙痒中是有效的，并且因此，在持续瘙痒是令人痛苦的症状的一些临床情况下可能是有用的。
The effectiveness of a eutectic mixture of the local anaesthetics lignocaine and prilocaine (EMLA cream) in relieving artifically induced pruritus was examined in 20 volunteers. The study was conducted in two parts. In part one, the effect of EMLA on the threshold concentration of histamine necessary to induce pruritus was assessed by a doule-blind placebo controlled method. In part two, the effect of EMLA on the perception of pruritus induced by the artificial pruritogens cowhage and papain was assessed by a single blind method. Some subjects were less sensitive to histamine after placebo cream treatment, but all subjects showed a marked reduction in sensitivity to histamine after EMLA treatment. The difference between EMLA and the placebo treatment was statistically significant. The EMLA preparation was found to be effective in alleviating pruritus induced by cowhage and papain and this effect was also statistically significant. Thus, EMLA cream was found to be effective in reducing experimentally induced pruritus and, therefore, may be useful in some clinical circumstances where persistent itch is a distressing symptom.