Influence of nucleus deformability on cell entry into cylindrical structures
Influence of nucleus deformability on cell entry into cylindrical structures
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DOI：
10.1007/s10237-013-0510-3
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发表时间：
2014-06-01
影响因子：
3.5
通讯作者：
Preziosi, L.
中科院分区：
文献类型：
--
作者：
Giverso, C.;Grillo, A.;Preziosi, L.
细胞核的机械特性已被证明在细胞跨细胞外网络和微通道的运动中发挥着重要作用。在这项工作中，我们重点关注细胞进入由细胞外基质组成的圆柱形通道的数学描述。为了获得细胞进入圆柱形结构的必要条件，导出了一种能量方法。细胞核被视为（i）作为围绕液滴的弹性膜或（ii）作为具有新胡克本构方程的不可压缩弹性材料。获得的结果强调了细胞核的机械变形性与细胞建立粘合键并由于肌球蛋白作用而在细胞骨架中产生主动力的能力之间相互作用的重要性。
The mechanical properties of cell nuclei have been demonstrated to play a fundamental role in cell movement across extracellular networks and micro-channels. In this work, we focus on a mathematical description of a cell entering a cylindrical channel composed of extracellular matrix. An energetic approach is derived in order to obtain a necessary condition for which cells enter cylindrical structures. The nucleus of the cell is treated either (i) as an elastic membrane surrounding a liquid droplet or (ii) as an incompressible elastic material with Neo-Hookean constitutive equation. The results obtained highlight the importance of the interplay between mechanical deformability of the nucleus and the capability of the cell to establish adhesive bonds and generate active forces in the cytoskeleton due to myosin action.