Delaying forelimb responses by microstimulation of macaque V1.
Delaying forelimb responses by microstimulation of macaque V1.
复制标题
通过微刺激猕猴 V1 延迟前肢反应。
DOI：
10.1007/s00221-007-0915-2
复制
发表时间：
2007
影响因子：
2
通讯作者：
Slocum,WarrenM
中科院分区：
文献类型：
--
作者：
Tehovnik,EdwardJ;Slocum,WarrenM
电微刺激猕猴V1先前已被证明延迟扫视眼球运动的点状视觉目标放置在受刺激的神经元的感受野。目前还不清楚这种延迟效应是否是眼系统特有的，或者这种效应是否也可以在骨骼运动系统中得到证实。为了解决这个问题，恒河猴被训练用其各自的手按下左或右杠杆，以响应出现在左或右半视野中的视觉目标。在50%的试验中，在视觉目标开始之前，将由100 μA，0.2 ms阳极优先脉冲组成的100 ms刺激序列传递到神经元。刺激V1延迟杠杆反应的执行时，视觉目标被定位在受刺激神经元的感受野内。我们认为微刺激V1引起的延迟效应很大程度上是由于视觉信号的中断，因为它是沿着膝状纹状体通路传输的。
Electrical microstimulation of macaque V1 has previously been shown to delay saccadic eye movements made to a punctate visual target placed in the receptive field of the stimulated neurons. It remains unclear whether this delay effect is specific to the oculomotor system or whether the effect can be demonstrated in the skeletomotor system as well. To address this question, a rhesus monkey was trained to depress a left or right lever with its respective hand in response to a visual target presented in the left or right hemifield. On 50% of trials, a 100 ms train of stimulation consisting of 100 μA, 0.2-ms anode-first pulses was delivered to the neurons before the onset of the visual target. Stimulation of V1 delayed the execution of the lever response when the visual target was positioned within the receptive field of the stimulated neurons. We suggest that the delay effect induced by microstimulation of V1 is largely due to a disruption of the visual signal as it is transmitted along the geniculostriate pathway.