Potassium Channelopathies and Gastrointestinal Ulceration.
Potassium Channelopathies and Gastrointestinal Ulceration.
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DOI：
10.5009/gnl15414
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发表时间：
2016-11-15
期刊：
影响因子：
3.4
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Han J;Lee SH;Giebisch G;Wang T
钾通道和转运体通过钾离子调节维持钾离子的稳态，并在多种不同的生物学作用中发挥重要作用。在过去的几十年里，钾通道和转运体参与胃酸的产生和胃分泌的调节的关键发现已经被认识到。用于治疗消化性溃疡的药物通常是钾转运体抑制剂。也有报道称钾通道与溃疡性结肠炎有关。非甾体抗炎药对肠道的直接毒性与钾通道活性的改变有关。一些报告表明，长期使用抗心绞痛药物尼可地尔，一种三磷酸腺苷敏感的钾通道开放剂，增加了胃肠道(GI)从口腔到肛门的溃疡和穿孔的机会。这些药物特征中的几个为进一步了解钾通道在胃肠道溃疡发生中的作用提供了进一步的见解。本综述的目的是调查钾通道病是否参与了整个胃肠道溃疡的发病机制。
Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and transporters are involved in the production of gastric acid and the regulation of secretion in the stomach have been recognized. Drugs used to treat peptic ulceration are often potassium transporter inhibitors. It has also been reported that potassium channels are involved in ulcerative colitis. Direct toxicity to the intestines from nonsteroidal anti-inflammatory drugs has been associated with altered potassium channel activities. Several reports have indicated that the long-term use of the antianginal drug Nicorandil, an adenosine triphosphate-sensitive potassium channel opener, increases the chances of ulceration and perforation from the oral to anal regions throughout the gastrointestinal (GI) tract. Several of these drug features provide further insights into the role of potassium channels in the occurrence of ulceration in the GI tract. The purpose of this review is to investigate whether potassium channelopathies are involved in the mechanisms responsible for ulceration that occurs throughout the GI tract.
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影响因子：
64.8
作者：
FELLENIUS, E;BERGLINDH, T;WALLMARK, B
通讯作者：
WALLMARK, B
影响因子：
11.5
作者：
Garnock-Jones, Karly P.
通讯作者：
Garnock-Jones, Karly P.
影响因子：
29.4
作者：
FOSTER, ES;JONES, WJ;BINDER, HJ
通讯作者：
BINDER, HJ
影响因子：
7.3
作者：
Alexander SP;Benson HE;Faccenda E;Pawson AJ;Sharman JL;Spedding M;Peters JA;Harmar AJ;CGTP Collaborators
通讯作者：
CGTP Collaborators
DOI：
10.1001/jama.1965.03080220027006
发表时间：
1965-01-01
影响因子：
--
作者：
BOLEY, SJ;SCHULTZ, L;ALLEN, AC
通讯作者：
ALLEN, AC