Antitumor effect of CPT-11, a camptothecin derivative, on human testicular tumor xenografts in nude mice.
Antitumor effect of CPT-11, a camptothecin derivative, on human testicular tumor xenografts in nude mice.
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喜树碱衍生物 CPT-11 对裸鼠人睾丸肿瘤异种移植物的抗肿瘤作用。
DOI：
10.1159/000474425
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发表时间：
1997
期刊：
影响因子：
23.4
通讯作者：
T. Kotake
中科院分区：
文献类型：
--
作者：
T. Miki;M. Sawada;N. Nonomura;Y. Kojima;A. Okuyama;O. Maeda;S. Saiki;T. Kotake
客观化
本文研究了喜树碱衍生物CPT-11对两种人睾丸胚胎癌(TTSC-2和TTSC-3)裸鼠异种移植瘤的抑制作用。
材料和方法
荷瘤裸鼠每日腹腔注射抗癌药物，每次0.1ml生理盐水，3次，间隔3d。实验结束后，切除肿瘤并进行光镜观察。
结果
给荷瘤小鼠腹腔注射CPT-11 10、30和50 mg/kg时，对TTSC-2和TTSC-3的抗肿瘤作用均呈剂量依赖关系。CPT-11联合顺铂30 mg/kg时，TTSC-2和TTSC-3肿瘤完全消退。组织学结果与治疗肿瘤的肿瘤体积缩小有很好的相关性。在单一药物和联合化疗中使用CPT-11治疗后，没有小鼠死亡。
结论
CPT-11化疗是治疗人睾丸肿瘤裸鼠异种移植瘤的一种有效、安全的方法。
OBJECTIVE
The antitumor effect of CPT-11, a camptothecin derivative, on two human testicular embryonal carcinomas (TTSC-2 and TTSC-3) heterotransplanted into-nude mice was studied.
MATERIALS AND METHODS
Tumor-bearing nude mice were given daily intraperitoneal injections of the anticancer drugs in 0.1 ml saline 3 times at 3-day intervals. At the end of the experiments tumors were resected and subjected to light-microscopic observation.
RESULTS
When 10, 30 and 50 mg/kg of CPT-11 was administered to tumor-bearing mice intraperitoneally, the antitumor effect of CPT-11 was observed dose-dependently in both TTSC-2 and TTSC-3. When 30 mg/kg of CPT-11 was administered in combination with CDDP, complete tumor regression was observed in both TTSC-2 and TTSC-3 tumors. Histological findings correlated well with the decrease in tumor volume of treated tumors. No mice died after treatment with CPT-11 in a single-agent and combination chemotherapy.
CONCLUSION
Chemotherapy with CPT-11 was an effective and safe method against human testicular tumors heterotransplanted in nude mice.