Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity
Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity
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DOI：
10.1136/adc.82.3.248
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发表时间：
2000-03-01
影响因子：
5.2
通讯作者：
Bleker, OP
中科院分区：
文献类型：
--
作者：
Ravelli, ACJ;van der Meulen, JHP;Bleker, OP
背景--人们普遍认为母乳喂养对婴幼儿的健康有好处。最近，一些研究表明，婴儿喂养方法也与成年后心血管疾病及其危险因素有关。目的-研究婴儿出生后第一周的喂养方法与48-53岁成年人的糖耐量、血脂、血压和体质量的关系。方法-1943年11月1日至1947年2月28日在阿姆斯特丹Wilhelmina Gashuis出生的受试者，大约在严重饥荒时期(1944年11月底至1945年5月初)出生。对于625名受试者，在出院时(平均出生后10.4天)可以获得关于婴儿喂养的信息，并且在隔夜禁食后至少可以获得一次血液样本。结果：在标准的口服葡萄糖耐量试验后，奶瓶喂养的受试者的平均血糖浓度高于纯母乳喂养的受试者。他们还具有较高的血浆低密度脂蛋白胆固醇浓度、较低的高密度脂蛋白胆固醇浓度和较高的低密度脂蛋白/高密度脂蛋白比率。婴儿喂养方式对血压和体质量指数无明显影响。结论纯母乳喂养对老年人心血管疾病的某些危险因素有一定的保护作用。
Background-It is generally accepted that breast feeding has a beneficial effect on the health of infants and young children. Recently, a few studies have shown that the method of infant feeding is also associated with cardiovascular disease and its risk factors in adult life.Aims-To examine the association between the method of infant feeding in the first weeks after birth and glucose tolerance, plasma lipid profile, blood pressure, and body mass in adults aged 48-53 years.Methods-Subjects born at term between 1 November 1943 and 28 February 1947 in the Wilhelmina Gasthuis in Amsterdam around the time of a severe period of famine (late November 1944 to early May 1945). For 625 subjects, information was available about infant feeding at the time of discharge from hospital (on average 10.4 days after birth), and at least one blood sample after an overnight fast.Results-Subjects who were bottle fed had a higher mean 120 minute plasma glucose concentration after a standard oral glucose tolerance test than those who were exclusively breast fed. They also had a higher plasma low density lipoprotein (LDL) cholesterol concentration, a lower high density lipoprotein (HDL) cholesterol concentration, and a higher LDL/ HDL ratio. Systolic blood pressure and body mass index were not affected by the method of infant feeding.Conclusions-Exclusive breast feeding seems to have a protective effect against some risk factors for cardiovascular disease in later life.