Serological Evidence of Henipavirus Exposure in Cattle, Goats and Pigs in Bangladesh
Serological Evidence of Henipavirus Exposure in Cattle, Goats and Pigs in Bangladesh
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DOI：
10.1371/journal.pntd.0003302
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发表时间：
2014-11-01
影响因子：
3.8
通讯作者：
Luby, Stephen P.
中科院分区：
文献类型：
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作者：
Chowdhury, Sukanta;Khan, Salah Uddin;Luby, Stephen P.
背景：尼帕病毒（NiV）是一种引起人类严重脑炎和呼吸道疾病的新发疾病。在马来西亚，猪被确定为NiV传播的中间宿主。自2001年以来，在孟加拉国，NiV已引起公认的人类疫情，三次疫情调查确定了与患病或死亡动物密切接触与人类疾病之间的流行病学关联。方法：我们检查了在人类NiV疫区的狐蝠栖息地周围饲养的牛和山羊。我们还测试了在另一项以日本脑炎为重点的研究中收集的猪血清。主要发现：采用基于luminex的多路微球法检测了26头牛（6.5%）、17头山羊（4.3%）和138头猪（44.2%）的NiV糖蛋白抗体；然而，这些抗体不能中和NiV。携带NiVsG抗体的牛和山羊更有可能有以蝙蝠或鸟类部分食用的水果为食（PR = 3.1, 95% CI 1.6-5.7）和饮用棕榈汁（PR = 3.9, 95% CI 1.5-10.2）的历史。结论：检测结果的差异可能是由于动物暴露于一种或多种与NiV抗原相似的新型病毒。进一步的研究可能会发现一种对公共卫生具有重要意义的新型生物。
Background: Nipah virus (NiV) is an emerging disease that causes severe encephalitis and respiratory illness in humans. Pigs were identified as an intermediate host for NiV transmission in Malaysia. In Bangladesh, NiV has caused recognized human outbreaks since 2001 and three outbreak investigations identified an epidemiological association between close contact with sick or dead animals and human illness.Methodology: We examined cattle and goats reared around Pteropus bat roosts in human NiV outbreak areas. We also tested pig sera collected under another study focused on Japanese encephalitis.Principal Findings: We detected antibodies against NiV glycoprotein in 26 (6.5%) cattle, 17 (4.3%) goats and 138 (44.2%) pigs by a Luminex-based multiplexed microsphere assay; however, these antibodies did not neutralize NiV. Cattle and goats with NiVsG antibodies were more likely to have a history of feeding on fruits partially eaten by bats or birds (PR = 3.1, 95% CI 1.6-5.7) and drinking palmyra palm juice (PR = 3.9, 95% CI 1.5-10.2).Conclusions: This difference in test results may be due to the exposure of animals to one or more novel viruses with antigenic similarity to NiV. Further research may identify a novel organism of public health importance.