Olfaction in patients with mild cognitive impairment and Alzheimer's disease
Olfaction in patients with mild cognitive impairment and Alzheimer's disease
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DOI：
10.1016/j.neurobiolaging.2006.11.014
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Chertkow, Howard
中科院分区：
文献类型：
--
作者：
Djordjevic, Jelena;Jones-Gotman, Marilyn;Chertkow, Howard
对阿尔茨海默病（AD）嗅觉功能障碍的了解仍然有限。特别是，它是不知道如何早期的过程中的疾病嗅觉缺陷发生，以及他们是否限于识别或涉及其他方面的嗅觉。我们研究了AD患者、轻度认知障碍（MCI）患者和正常老年对照（NEC）参与者的嗅觉（气味检测阈值、质量辨别和识别）和认知（注意力、推理、记忆、命名和流畅性）功能。MCI患者的嗅觉敏感性和识别能力受损，而异常阈值可解释辨别缺陷。AD患者在所有三个领域都受损，并且比MCI组更糟。气味歧视（OD）和识别性能的相关性更显着比检测阈值与性能的神经心理测试。我们的结论是嗅觉检测阈值和识别缺陷发生在AD早期，在临床症状完全发展之前，并在疾病过程中进一步下降。高检测阈值，连同受损的识别，可能是有用的AD的早期指标。(c)2006年爱思唯尔公司All rights reserved.
Understanding of olfactory dysfunction in Alzheimer's disease (AD) remains limited. In particular, it is not known how early in the course of the disease olfactory deficits occur, and whether they are restricted to identification or involve other aspects of olfaction. We studied olfactory (odor detection thresholds, quality discrimination, and identification) and cognitive (attention, reasoning, memory, naming and fluency) functioning in patients with AD, with mild cognitive impairment (MCI), and in normal elderly control (NEC) participants. MCI patients were impaired in olfactory sensitivity and identification, while a discrimination deficit was accounted for by abnormal thresholds. AD patients were impaired in all three domains, and were worse than the MCI group. Odor discrimination (OD) and identification performance correlated more prominently than detection thresholds with performance on neuropsychological tests. We concluded that deficits in olfactory detection thresholds and identification occur early in AD, before clinical symptoms are fully developed, and decline further over the course of the disease. High detection thresholds, together with impaired identification, may be useful as an early indicator of AD. (c) 2006 Elsevier Inc. All rights reserved.