Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.
Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.
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DOI：
10.3389/fphar.2014.00110
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发表时间：
2014
影响因子：
5.6
通讯作者：
Edwards AG
中科院分区：
文献类型：
--
作者：
Vincent KP;McCulloch AD;Edwards AG
Calcium/calmodulin-dependent protein kinase II (CaMKII) activity has been shown to contribute to arrhythmogenesis in a remarkably broad range of cardiac pathologies. Several of these involve significant structural and electrophysiologic remodeling, whereas others are due to specific channelopathies, and are not typically associated with arrhythmogenic changes to protein expression or cellular and tissue structure. The ability of CaMKII to contribute to arrhythmia across such a broad range of phenotypes suggests one of two interpretations regarding the role of CaMKII in cardiac arrhythmia: (1) some CaMKII-dependent mechanism is a common driver of arrhythmia irrespective of the specific etiology of the disease, or (2) these different etiologies expose different mechanisms by which CaMKII is capable of promoting arrhythmia. In this review, we dissect the available mechanistic evidence to explore these two possibilities and discuss how the various molecular actions of CaMKII promote arrhythmia in different pathophysiologic contexts.
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影响因子：
5
作者：
Camors E;Mohler PJ;Bers DM;Despa S
通讯作者：
Despa S
DOI：
10.1161/circep.113.000400
发表时间：
2013-06
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
Aiba T;Barth AS;Hesketh GG;Hashambhoy YL;Chakir K;Tunin RS;Greenstein JL;Winslow RL;Kass DA;Tomaselli GF
通讯作者：
Tomaselli GF
影响因子：
15.9
作者：
Backs, Johannes;Song, Kunhua;Olson, Eric N.
通讯作者：
Olson, Eric N.
DOI：
10.1073/pnas.0511322103
发表时间：
2006-03-07
影响因子：
11.1
作者：
Erxleben, C;Liao, YH;Armstrong, DL
通讯作者：
Armstrong, DL
影响因子：
9
作者：
通讯作者：
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