Irreversible cell-cycle transitions are due to systems-level feedback
Irreversible cell-cycle transitions are due to systems-level feedback
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DOI：
10.1038/ncb0707-724
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发表时间：
2007-07-01
影响因子：
21.3
通讯作者：
Csikasz-Nagy, Attila
中科院分区：
文献类型：
--
作者：
Novak, Bela;Tyson, John J.;Csikasz-Nagy, Attila
细胞周期转换的不可逆性通常被认为是来自某些调节蛋白的不可逆降解。我们认为，细胞周期（或任何其他分子控制系统）中的不可逆转变不能归因于单个分子或反应，而是来自反应网络中的反馈信号。这种系统层面的不可逆性观点得到了许多实验观察的支持。
The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle ( or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.