A chemical study of cyclic depsipeptides produced by a sponge-derived fungus
A chemical study of cyclic depsipeptides produced by a sponge-derived fungus
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DOI：
10.1021/np060178k
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发表时间：
2006-11-27
影响因子：
5.1
通讯作者：
Crews, Phillip
中科院分区：
文献类型：
--
作者：
Amagata, Taro;Morinaka, Brandon I.;Crews, Phillip
从一种海绵状真菌海水培养的细胞毒提取物中分离出两种新的环状沉积肽，guangomides A(1)和B(2)，以及一种新的消菌素衍生物(3)。通过对大量一维和二维核磁共振数据集的分析，确定了新结构；通过x射线和Marfey方法结构分析，确定了1的2S、9S、13S、19S、24R、28R的绝对构型。2的绝对构型是相同的。发现提取物的细胞毒性是由于brefeldin A，而1和2对表皮葡萄球菌和杜兰肠球菌表现出较弱的抗菌活性。
Two novel cyclic depsipeptides, guangomides A (1) and B (2), together with a new destruxin derivative ( 3) were isolated from the cytotoxic extract obtained from the saltwater culture of an unidentifiable sponge-derived fungus. The new structures were elucidated on the basis of analysis of extensive 1D and 2D NMR data sets, and the absolute configurations of 2S, 9S, 13S, 19S, 24R, 28R of 1 were determined on the basis of the combined X-ray and Marfey's method structure analysis. Identical absolute configurations were assumed for 2. The cytotoxicity of the extract was found to be due to brefeldin A, while 1 and 2 showed weak antibacterial activity against Staphylococcus epidermidis and Enterococcus durans.