Predicting evolutionary patterns of mammalian teeth from development
Predicting evolutionary patterns of mammalian teeth from development
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DOI：
10.1038/nature06153
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发表时间：
2007-09-27
期刊：
影响因子：
64.8
通讯作者：
Jernvall, Jukka
中科院分区：
文献类型：
--
作者：
Kavanagh, Kathryn D.;Evans, Alistair R.;Jernvall, Jukka
研究发展的动机之一是发现可能指导进化变化的机制。在这里，我们报告发育如何控制小鼠颊齿或臼齿的相对大小和数量。我们通过实验揭示牙齿连续发育的激活剂-抑制剂逻辑，构建了抑制级联模型。抑制级联就像一个棘轮，决定了颌骨上的磨牙大小差异，其中一个影响是第二磨牙始终占总磨牙面积的三分之一。通过使用宏观进化测试，我们证明了该模型在预测不同饮食的鼠类啮齿动物物种的牙列模式方面的成功，从而提供了沿着发育有利轨迹的生态驱动进化的例子。总的来说，我们的工作演示了如何在自然系统中构建和测试具有进化可预测性的发育规则。
One motivation in the study of development is the discovery of mechanisms that may guide evolutionary change. Here we report how development governs relative size and number of cheek teeth, or molars, in the mouse. We constructed an inhibitory cascade model by experimentally uncovering the activator-inhibitor logic of sequential tooth development. The inhibitory cascade acts as a ratchet that determines molar size differences along the jaw, one effect being that the second molar always makes up one-third of total molar area. By using a macroevolutionary test, we demonstrate the success of the model in predicting dentition patterns found among murine rodent species with various diets, thereby providing an example of ecologically driven evolution along a developmentally favoured trajectory. In general, our work demonstrates how to construct and test developmental rules with evolutionary predictability in natural systems.