Association of preoperative serum IGF- I concentration with clinicopathological parameters in patients with non-small cell lung cancer
Association of preoperative serum IGF- I concentration with clinicopathological parameters in patients with non-small cell lung cancer
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DOI：
10.1007/s11596-013-1101-3
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发表时间：
2013-04-01
影响因子：
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通讯作者：
Fu, Xiang-ning
中科院分区：
文献类型：
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作者：
Fu, Sheng-ling;Tang, He-xiao;Fu, Xiang-ning
胰岛素样生长因子-I（IGF-I）是一种促有丝分裂和抗凋亡因子。血清IGF-I浓度与某些癌症风险和肿瘤进展相关。本研究旨在探讨术前血清IGF-I浓度与非小细胞肺癌（NSCLC）临床病理参数及预后的关系。采用酶联免疫吸附法（ELISA）测定80例肺癌根治术患者和45例肺良性病变（BPL）患者术前血清IGF-I浓度。结果表明，血清IGF-I浓度升高，并与临床病理参数和总生存期（OS）的NSCLC患者。NSCLC患者血清IGF-I浓度显著高于BPL患者。IGF-I浓度在T2、N1-3和IIIA-IV的NSCLC患者中显著较高，但在< T2、N 0或IA-IIB的患者中则不显著。血清IGF-I浓度升高与预后不良显著相关。我们的数据首次显示IGF-I血清浓度与肿瘤大小之间呈正相关。IGF-I与肺癌的发生发展可能依赖于自分泌/旁分泌功能。此外，我们的研究显示，血清IGF-I浓度较高与肿瘤较大、晚期、局部淋巴结转移和预后较差相关，表明内分泌IGF-I在NSCLC的进展中也很重要。
Insulin-like growth factor-I (IGF-I) is a mitogenic and anti-apoptotic factor. Serum IGF-I concentration is related to some cancer risk and tumor progression. The aim of this research was to study the association of preoperative serum IGF-I concentration with clinicopathological parameters and prognosis of non-small cell lung cancer (NSCLC). Preoperative serum IGF-I concentration was measured in 80 consecutive patients with NSCLC who underwent radical lung cancer resection, and 45 patients with benign pulmonary lesion (BPL) by using enzyme linked immunosorbent assay (ELISA). The results showed that the serum IGF-I concentration was elevated and correlated with clinicopathological parameters and overall survival (OS) in NSCLC patients. Serum IGF-I concentration was significantly higher in patients with NSCLC than in those with BPL. The IGF-I concentrations were significantly higher in NSCLC patients with a parts per thousand yenT2, N1-3, and in IIIA-IV but not in those with < T2, N0, or IA-IIB. The increased serum IGF-I concentration was significantly correlated with poor prognosis. Our data show the positive correlation between IGF-I serum concentration and the tumor size for the first time. It seems that IGF-I related to the progression of lung cancer may depend on autocrine/paracrine function. In addition, our study reveals that higher serum IGF-I concentration is correlated with larger tumor size, advanced stages, local lymph node metastasis and worse prognosis, indicating that endocrine IGF-I is also important for the progression for NSCLC.