Differences in the regulation of aldehyde dehydrogenase genes inAspergillus niger andAspergillus nidulans
Differences in the regulation of aldehyde dehydrogenase genes inAspergillus niger andAspergillus nidulans
复制标题
黑曲霉和构巢曲霉醛脱氢酶基因调控的差异
作者：
M. O’Connell;J. Kelly
为了研究INA的基因调控机制。尼日尔，并将这些系统与INA的类似系统进行比较。Nidulans是一种编码乙醛脱氢酶的基因，已被克隆。野生型菌株OFA。该基因的表达受诱导和抑制的调节。在不同的生长条件下，不同化合物的诱导水平和抑制程度与Thea所见的不同。Nidulans alda基因。与根结线虫Alda基因不同的是，Thea。Niger基因既有碳分解代谢抑制机制，也有非抑制诱导机制。茶树异源表达的研究。尼日尔基因ina。Nidulans已经证明它的表达受alcR基因产物OFA的调控。尼杜兰。
SummaryIn order to study mechanisms of gene regulation inA. niger, and to compare these to similar systems inA. nidulans, a gene encoding an aldehyde dehydrogenase enzyme has been cloned. In wild-type strains ofA. niger the gene shows expression which is regulated by induction and repression. Levels of induction by various compounds and the extent of repression under various growth conditions differs from that seen for theA. nidulans aldA gene. Unlike the A.nidulans aldA gene, theA. niger gene has both carbon catabolite repressible and nonrepressible induction mechanisms. Studies of heterologous expression of theA. niger gene inA. nidulans have shown that its expression is regulated by thealcR gene product ofA. nidulans.