Model simulation of the SPOC wave in a bundle of striated myofibrils.
Model simulation of the SPOC wave in a bundle of striated myofibrils.
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DOI：
10.2142/biophysico.13.0_217
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发表时间：
2016
影响因子：
1.5
通讯作者：
Ishiwata S
中科院分区：
文献类型：
--
作者：
Nakagome K;Sato K;Shintani SA;Ishiwata S
自发性振荡收缩（SPOC）是横纹肌在中间激活条件下的一种现象。最近，我们构建了一个肌节的SPOC理论模型，一个单位肌节模型，它解释了SPOC在每个肌节水平上的行为。我们还构建了单个肌原纤维模型，该模型粘弹性串联了单元模型，并在肌原纤维水平上解释了SPOC的行为。在本研究中，为了了解一束肌原纤维的SPOC特性，我们将单个肌原纤维模型扩展到二维（2D）模型和三维（3D）模型，其中肌原纤维通过z线和m线之间的交联剂弹性地并排连接。通过选择交联剂和外弹簧弹性常数的不同值，二维和三维肌原纤维模型可以再现实验中观察到的二维和三维肌原纤维中的各种SPOC波模式。这些2D和3D肌原纤维模型的结果提供了对高阶肌原纤维组装的SPOC特性的深入了解。
SPOC (spontaneous oscillatory contraction) is a phenomenon observed in striated muscle under intermediate activation conditions. Recently, we constructed a theoretical model of SPOC for a sarcomere, a unit sarcomere model, which explains the behavior of SPOC at each sarcomere level. We also constructed a single myofibril model, which visco-elastically connects the unit model in series, and explains the behaviors of SPOC at the myofibril level. In the present study, to understand the SPOC properties in a bundle of myofibrils, we extended the single myofibril model to a two-dimensional (2D) model and a three-dimensional (3D) model, in which myofibrils were elastically connected side-by-side through cross-linkers between the Z-lines and M-lines. These 2D and 3D myofibril models could reproduce various patterns of SPOC waves experimentally observed in a 2D sheet and a 3D bundle of myofibrils only by choosing different values of elastic constants of the cross-linkers and the external spring. The results of these 2D and 3D myofibril models provide insight into the SPOC properties of the higher-ordered assembly of myofibrils.