Effects of maternal ethanol ingestion on the uptake of alpha-aminoisobutyric acid by fetal rat liver, lung and brain.
Effects of maternal ethanol ingestion on the uptake of alpha-aminoisobutyric acid by fetal rat liver, lung and brain.
复制标题
母体乙醇摄入对胎鼠肝、肺和脑吸收α-氨基异丁酸的影响。
DOI：
10.1159/000243135
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Eman,S
中科院分区：
文献类型：
--
作者：
Snyder,AK;Singh,SP;Pullen,GL;Eman,S
与配对喂养或自由喂养对照组相比，母体乙醇摄入减少了胎盘和胎仔肝脏、肺和脑对[14 C]-α-氨基异丁酸（AIB）的摄取。胎儿组织和血浆放射性之间的比率表明，减少AIB运输到组织的乙醇喂养的胎儿。器官重量与胎儿：母体血浆14 C比率（胎盘AIB转移速率的指标）和组织AIB摄取相关。这些观察结果表明，乙醇诱导的生长迟缓可能反映了运输过程受损导致的营养供应减少。
Maternal ethanol ingestion reduced the uptake of [14C]-α-aminoisobutyric acid (AIB) by placenta and fetal liver, lung and brain when compared with pair-fed or ad libitum-fed controls. The ratios between fetal tissue and plasma radioactivities indicated reduced AIB transport into the tissues of the ethanol-fed fetuses. Organ weights correlated with the fetal:maternal plasma14C ratio, an indicator of the rate of placental AIB transfer, and with the tissue AIB uptake. These observations suggest that ethanol-induced growth retardation may reflect reduced nutrient availability resulting from impaired transport processes.