Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents
Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents
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DOI：
10.1016/s0968-0896(01)00245-0
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发表时间：
2001-09-01
影响因子：
3.5
通讯作者：
Taylor, JS
中科院分区：
文献类型：
--
作者：
Ma, ZC;Taylor, JS
最近，我们描述了一种用于设计高选择性抗病毒和抗癌化疗剂的新概念，其利用疾病特异性核酸序列来模板化前药与催化剂的缔合，所述催化剂催化药物的释放。在这里，我们报告的错配，空间位阻，和电子的药物和探针释放的速率和特异性在两个和三个组件的模型系统的影响，并在人血清中的前药接头的稳定性。(C)2001爱思唯尔科技有限公司版权所有。
Recently, we described a new concept for the design of highly selective antiviral and anticancer chemotherapeutic agents that makes use of a disease-specific nucleic acid sequence to template the association of-a prodrug with a catalyst which catalyzes the release of the drug. Herein, we report on the effect of mismatches, sterics, and electronics on the rate and specificity of drug and probe release in both two and three component model systems, and on the stability of the prodrug linker in human serum. (C) 2001 Elsevier Science Ltd. All rights reserved.