A microcapillary flow disc reactor for organic synthesis
A microcapillary flow disc reactor for organic synthesis
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DOI：
10.1021/op700015f
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发表时间：
2007-05-01
影响因子：
3.4
通讯作者：
Ley, Steven V.
中科院分区：
文献类型：
--
作者：
Hornung, Christian H.;Mackley, Malcolm R.;Ley, Steven V.
本文报告了新型塑料微毛细管流盘 (MFD) 反应器的概念验证、开发和试验。 MFD 由柔性塑料微毛细管薄膜 (MCF) 构成，包含直径在 80-250 μm 范围内的平行毛细管通道。 MCF 被缠绕成螺旋状并经过热处理形成实心圆盘，然后能够在升高的温度和压力下以及受控的停留时间下进行连续流动反应。系统中进行了三个反应方案，即恶唑的合成、烯丙基醚的形成和Diels-Alder反应。每天的反应规模可达四公斤。将 MFD 技术的潜在优势与其他反应器几何形状（包括传统实验室规模和其他微型设备）的潜在优势进行了比较。
This paper reports proof of concept, development, and trials for a novel plastic microcapillary flow disc (MFD) reactor. The MFD was constructed from a flexible, plastic microcapillary film (MCF), comprising parallel capillary channels with diameters in the range of 80-250 mu m. MCFs were wound into spirals and heat treated to form solid discs, which were then capable of carrying out continuous flow reactions at elevated temperatures and pressures and with a controlled residence time. Three reaction schemes were conducted in the system, namely the synthesis of oxazoles, the formation of an allyl-ether, and a Diels-Alder reaction. Reaction scales of up to four kilograms per day could be achieved. The potential benefits of the MFD technology are compared against those of other reactor geometries including both conventional lab-scale and other microscale devices.