International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
International consensus diagnostic criteria for neuromyelitis optica spectrum disorders.
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DOI：
10.1212/wnl.0000000000001729
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发表时间：
2015-07-14
期刊：
影响因子：
9.9
通讯作者：
International Panel for NMO Diagnosis
中科院分区：
文献类型：
--
作者：
Wingerchuk DM;Banwell B;Bennett JL;Cabre P;Carroll W;Chitnis T;de Seze J;Fujihara K;Greenberg B;Jacob A;Jarius S;Lana-Peixoto M;Levy M;Simon JH;Tenembaum S;Traboulsee AL;Waters P;Wellik KE;Weinshenker BG;International Panel for NMO Diagnosis
视神经肌萎缩症（NMO）是一种与多发性硬化症（MS）不同的炎性CNS综合征，与血清水通道蛋白-4免疫球蛋白G抗体（AQP 4-IgG）相关。先前的NMO诊断标准需要视神经和脊髓受累，但可能发生更受限或更广泛的CNS受累。国际NMO诊断小组（IPND）召开会议，利用系统的文献综述和电子调查来制定修订的诊断标准，以促进共识。新的命名法定义了统一的术语NMO谱系障碍（NMOSD），并通过血清学检测（NMOSD伴或不伴AQP 4-IgG）进一步分层。具有AQP 4-IgG的NMOSD患者所需的核心临床特征包括与视神经、脊髓、最后区、其他脑干、间脑或大脑表现相关的临床综合征或MRI结果。诊断无AQP 4-IgG的NMOSD或血清学检测不可用时，需要更严格的临床标准和额外的神经影像学结果。IPND还提出了验证策略，并就儿科NMOSD诊断以及单相NMOSD和视脊髓MS的概念达成了共识。
Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.