MOLECULAR BASIS FOR GENETIC CODE
MOLECULAR BASIS FOR GENETIC CODE
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DOI：
10.1073/pnas.55.4.966
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发表时间：
1966-01-01
影响因子：
11.1
通讯作者：
DUGRE, SA
中科院分区：
文献类型：
--
作者：
WOESE, CR;DUGRE, DH;DUGRE, SA
1966年1月17日，S.Spiegelman提出遗传密码的中心问题是识别引起观察到的密码子分配的因素。特别是，关键问题是氨基酸-寡核苷酸空间相互作用是否在决定这些密码子分配中起作用，如果是，在多大程度上起决定作用。虽然一开始没有与这一问题有关的相关事实，但最初肯定不缺乏理论推测。Gamowa和其他人认为氨基酸-寡核苷酸空间相互作用是决定密码子分配的唯一因素。
Communicated by S. Spiegelman, January 17, 1966 The central problem ofthe genetic code is to identify the factors giving rise to the observed codon assignments. In particular, the key issueis whether or not amino acid-oligonucleotide steric interactions play or have played a role in de-termining these assignments, and if so, to what extent.'Although in the beginning there were no pertinent facts bearing on this matter, there initially was certainly no dearth of theoretical speculation. Gamowand others assumed amino acidnucleic acid steric interactions to be the sole factors determining codon assignments. 2