Maternal antibodies reduce costs of an immune response during development
Maternal antibodies reduce costs of an immune response during development
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DOI：
10.1242/jeb.012344
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发表时间：
2008-03-01
影响因子：
2.8
通讯作者：
Grindstaff, Jennifer L.
中科院分区：
文献类型：
--
作者：
Grindstaff, Jennifer L.
幼年脊椎动物主要依赖先天免疫和母源抗体来进行免疫防御。这种对先天免疫和相关炎症反应的依赖通常会导致抗原攻击后生长速度降低。然而，如果后代具有识别抗原的母体抗体，这些抗体应该阻止炎症反应的刺激并减少生长抑制。为了确定母体和/或后代抗原暴露是否影响抗体传播和后代生长，对雌性日本鹌鹑（Coturnix japonica）及其新孵化的雏鸟进行了免疫。母亲们接受脂多糖（LPS）、灭活禽呼肠孤病毒疫苗（AR）免疫，或注射对照磷酸盐缓冲盐水。在每个家庭中，三分之一的后代接受 LPS 免疫，三分之一接受 AR 免疫，三分之一接受对照治疗。母亲免疫接种显着影响所传播的特定类型的抗体。一般来说，免疫抑制了后代的生长。然而，与使用不同抗原免疫的兄弟姐妹相比，使用与其母亲相同的抗原免疫的后代表现出更高的生长。这表明，母体抗体的存在可以部分改善发育过程中抗原暴露的生长抑制作用，但在缺乏特定母体抗体的情况下，后代依赖于更昂贵的先天免疫防御。总之，结果表明，母亲在繁殖前的局部疾病环境显着影响母源抗体的传播，这些母源抗体除了提供被动体液免疫防御之外，还可能使后代在感染期间部分维持生长。
Young vertebrates are dependent primarily on innate immunity and maternally derived antibodies for immune defense. This reliance on innate immunity and the associated inflammatory response often leads to reduced growth rates after antigenic challenge. However, if offspring have maternal antibodies that recognize an antigen, these antibodies should block stimulation of the inflammatory response and reduce growth suppression. To determine whether maternal and/or offspring antigen exposure affect antibody transmission and offspring growth, female Japanese quail ( Coturnix japonica) and their newly hatched chicks were immunized. Mothers were immunized with lipopolysaccharide (LPS), killed avian reovirus vaccine (AR), or were given a control, phosphate-buffered saline, injection. Within each family, one-third of offspring were immunized with LPS, one-third were immunized with AR, and one-third were given the control treatment. Maternal immunization significantly affected the specific types of antibodies that were transmitted. In general, immunization depressed offspring growth. However, offspring immunized with the same antigen as their mother exhibited elevated growth in comparison to siblings immunized with a different antigen. This suggests that the growth suppressive effects of antigen exposure during development can be partially ameliorated by the presence of maternal antibodies, but in the absence of specific maternal antibodies, offspring are dependent on more costly innate immune defenses. Together, the results suggest that the local disease environment of mothers prior to reproduction significantly affects maternal antibody transmission and these maternal antibodies may allow offspring to partially maintain growth during infection in addition to providing passive humoral immune defense.