Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999-2018.
Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999-2018.
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1999-2018 年美国国家健康和营养检查调查中的健康生活方式行为和生物衰老。
DOI：
10.1093/gerona/glad082
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gu,Yian
中科院分区：
文献类型：
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作者：
Thomas,Aline;Belsky,DanielW;Gu,Yian
均衡饮食和多参加体育活动的人寿命更长，更健康。这项研究旨在验证这一假设，即这些关联反映了衰老的生物学过程减缓。我们分析了1999-2018年国家健康和营养检查调查（NHANES）的42625名参与者（年龄在20-84岁之间，51%为女性参与者）的数据。我们使用标准方法计算了地中海饮食（Medi）和休闲时间体力活动（LTPA）水平。我们通过应用PhenoAge算法来测量生物老化，该算法是使用NHANES-III（1988-94）的临床和死亡率数据开发的，用于在调查时从抽血测量的临床化学。我们测试了饮食和身体活动措施与生物衰老的关联，探讨了这些健康行为之间的协同作用，并测试了年龄，性别和体重指数之间的异质性。与那些生活方式不太健康的人相比，坚持Medi和做更多LTPA的参与者的生物学年龄更小（高与低Medi三分位数：β = 0.14标准差[SD] [95%置信区间{CI}：-0.18，-0.11];在控制人口统计学和社会经济学特征的模型中，高LTPA vs久坐LTPA，β = 0.12SD[-0.15，-0.09]）。健康的饮食和规律的体力活动与较低的临床定义的生物衰老独立相关，无论年龄，性别和BMI类别如何。
People who have a balanced diet and engage in more physical activity live longer, healthier lives. This study aimed to test the hypothesis that these associations reflect a slowing of biological processes of aging. We analyzed data from 42 625 participants (aged 20–84 years, 51% female participants) from the National Health and Nutrition Examination Surveys (NHANES), 1999–2018. We calculated adherence to a Mediterranean diet (MeDi) and level of leisure time physical activity (LTPA) using standard methods. We measured biological aging by applying the PhenoAge algorithm, developed using clinical and mortality data from NHANES-III (1988–94), to clinical chemistries measured from a blood draw at the time of the survey. We tested the associations of diet and physical activity measures with biological aging, explored synergies between these health behaviors, and tested heterogeneity in their associations across strata of age, sex, and body mass index. Participants who adhered to the MeDi and who did more LTPA had younger biological ages compared with those who had less-healthy lifestyles (high vs low MeDi tertiles: β = 0.14 standard deviation [SD] [95% confidence interval {CI}: −0.18, −0.11]; high vs sedentary LTPA, β = 0.12SD[−0.15, −0.09]), in models controlled for demographic and socioeconomic characteristics. Healthy diet and regular physical activity were independently associated with lower clinically defined biological aging, regardless of age, sex, and BMI category.