Mechanisms of Invasion in Head and Neck Cancer.
Mechanisms of Invasion in Head and Neck Cancer.
复制标题
DOI：
10.5858/arpa.2014-0498-ra
复制
发表时间：
2015-11
影响因子：
4.6
通讯作者：
Segall JE
中科院分区：
文献类型：
--
作者：
Jimenez L;Jayakar SK;Ow TJ;Segall JE
头颈部鳞状细胞癌(HNSCC)表现出的高度侵袭性常与患者局部复发和淋巴结转移有关，也是导致晚期疾病患者预期5年生存率约50%的关键因素。了解HNSCC侵袭的特点和介质是重要的，以便开发新的治疗方法。概述HNSCC侵袭的特点、介体和机制。PubMed上关于HNSCC侵袭的同行评议文章的文献综述。HNSCC肿瘤的组织学特征有助于预测预后和影响临床治疗决策。细胞表面受体、信号通路、蛋白水解酶、内翻足功能、上皮-间充质转化、microRNAs和肿瘤微环境等都参与了HNSCC细胞侵袭行为的调控。寻找有效的HNSCC侵袭抑制剂有可能通过降低扩散速度和提高对化疗的反应性来改善患者的预后。
The highly invasive properties demonstrated by Head and Neck Squamous Cell Carcinoma (HNSCC) is often associated with locoregional recurrence and lymph node metastasis in patients, and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed. To provide an overview of the characteristics, mediators and mechanisms of HNSCC invasion. A literature review of peer-reviewed articles in PubMed on HNSCC invasion. Histological features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.