Inadequacy of cardiovascular risk factor management in chronic kidney transplantation - evidence from the FAVORIT study.
Inadequacy of cardiovascular risk factor management in chronic kidney transplantation - evidence from the FAVORIT study.
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DOI：
10.1111/j.1399-0012.2012.01676.x
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发表时间：
2012-07
影响因子：
2.1
通讯作者：
Kusek JW
中科院分区：
文献类型：
--
作者：
Carpenter MA;Weir MR;Adey DB;House AA;Bostom AG;Kusek JW
肾移植接受者（KTRs）患心血管疾病（CVD）的风险增加。我们的目标是用标准标准描述心血管疾病危险因素的流行情况，并在当代ktr中使用降低心血管疾病危险因素的药物。叶酸对移植血管预后降低的研究纳入并收集了4107例同型半胱氨酸升高且移植后平均5年移植物功能稳定的ktr患者的药物数据。心血管疾病的危险因素是常见的（高血压或使用降压药92%，低密度脂蛋白水平或升高或使用降脂药66%，糖尿病史41%，肥胖38%）；20%的研究参与者报告了心血管疾病的流行。69%的参与者没有达到国家肾脏基金会血压（BP）指南（BP < 130/80 mm Hg）。44%服用抗高血压药物的患者存在未控制的高血压（血压140/90 mm Hg或更高）；18%的受试者LDL处于临界或升高状态，其中60%未接受治疗，31%的CVD患者未使用抗血小板药物。在肾移植受者中，有机会改善治疗和控制传统的心血管疾病危险因素。
Kidney transplant recipients (KTRs) have increased risk for cardiovascular disease (CVD). Our objective is to describe the prevalence of CVD risk factors applying standard criteria and use of CVD risk factor lowering medications in contemporary KTRs. The Folic Acid for Vascular Outcome Reduction in Transplantation study enrolled and collected medication data on 4,107 KTRs with elevated homocysteine and stable graft function an average of 5 years post-transplant. CVD risk factors were common (hypertension or use of blood pressure lowering medication in 92%, borderline or elevated LDL or use of lipid-lowering agent in 66%, history of diabetes mellitus in 41%, and obesity in 38%); prevalent CVD was reported in 20% of study participants. National Kidney Foundation blood pressure (BP) guidelines (BP < 130/80 mm Hg) were not met by 69% of participants. Uncontrolled hypertension (BP of 140/90 mm Hg or higher) was present in 44% of those taking anti-hypertension medication; 18% of participants had borderline or elevated LDL, of which 60% were untreated, and 31% of the participants with prevalent CVD were not using an anti-platelet agent. There is opportunity to improve treatment and control of traditional CVD risk factors in kidney transplant recipients.
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影响因子：
13.6
作者：
Kasiske, BL;Chakkera, HA;Roel, J
通讯作者：
Roel, J
影响因子：
168.9
作者：
Matsushita, Kunihiro;van der Velde, Marije;Astor, Brad C.;Woodward, Mark;Levey, Andrew S.;de Jong, Paul E.;Coresh, Josef;Gansevoort, Ron T.
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Gansevoort, Ron T.
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2.8
作者：
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13.6
作者：
Foley, Robert N.;Collins, Allan J.
通讯作者：
Collins, Allan J.
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158.5
作者：
Haller, Hermann;Ito, Sadayoshi;Viberti, Giancarlo
通讯作者：
Viberti, Giancarlo