QUANTIFICATION OF ADIPOSE-TISSUE BY MRI - RELATIONSHIP WITH ANTHROPOMETRIC VARIABLES
QUANTIFICATION OF ADIPOSE-TISSUE BY MRI - RELATIONSHIP WITH ANTHROPOMETRIC VARIABLES
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DOI：
10.1152/jappl.1992.72.2.787
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发表时间：
1992-02-01
影响因子：
3.3
通讯作者：
GUARDO, R
中科院分区：
文献类型：
--
作者：
ROSS, R;LEGER, L;GUARDO, R
本研究有两个目标：1) 建立磁共振成像 (MRI) 作为测量人体总脂肪组织和局部脂肪组织 (AT) 分布的工具；2) 评估选定的人体测量变量与 MRI 测量的 AT 之间的关系。 27 名健康男性参与了这项研究，其年龄 [40.8 +/- 14.5 (SD) 年]、体重指数 (28.5 +/- 4.8) 和腰臀比 (WHR，0.96 +/- 0.07) 各不相同。 总 AT 体积是通过对从头到脚（10 毫米厚度，50 毫米中心）连续切片（n = 41）获得的 AT 面积进行线性插值来确定的。 重复测量总 AT 体积的平均变化为 2.9%（范围 0.9-4.3%）。 总 AT 体积（6.9-59.3 升）、皮下 AT（6.3-49.8 升）和内脏 AT（0.5-8.5 升）观察到较大的个体差异。 内脏AT占总AT的18.3%。 总肥胖的单一最佳预测因子是腰围（R2 = 0.92）。 对于内脏 AT 体积，腰臀比是最强的人体测量相关性（r = 0.85，P < 0.01）。 然而，当控制年龄和肥胖度时，腰臀比只能解释 12% 的绝对内脏 AT 变化和 < 1% 的内脏与皮下比率变化。 与肥胖水平或腰臀比相比，年龄是内脏与皮下比率的更好预测指标。 这项研究的结果表明，MRI 可以可靠地测量人类区域和总 AT 分布，因此作为一种研究工具具有价值。
This study had two objectives: 1) to establish magnetic resonance imaging (MRI) as a tool for measuring total and regional adipose tissue (AT) distribution in humans and 2) to assess the relationship between selected anthropometric variables and MRI-measured AT. Twenty-seven healthy men varying in age [40.8 +/- 14.5 (SD) yr], body mass index (28.5 +/- 4.8), and waist-to-hip ratio (WHR, 0.96 +/- 0.07) participated in the study. Total AT volume was determined using a linear interpolation of AT areas obtained on consecutive slices (n = 41) taken from head to toe (10-mm thickness, 50-mm centers). The mean change for repeated measures of total AT volume was 2.9% (range 0.9-4.3%). Large interindividual differences were observed for total AT volume (6.9-59.3 liters), subcutaneous AT (6.3-49.8 liters), and visceral AT (0.5-8.5 liters). Visceral AT represented 18.3% of the total AT. The single best predictor of total adiposity was waist circumference (R2 = 0.92). For visceral AT volume, WHR was the strongest anthropometric correlate (r = 0.85, P < 0.01). When controlled for age and adiposity, however, WHR explained only 12% of the variation in absolute visceral AT and < 1% of the variation in visceral-to-subcutaneous ratio. Age was a better predictor of visceral-to-subcutaneous ratio than level of adiposity or WHR. The results of this study demonstrate that MRI offers a reliable measure of regional and total AT distribution in humans and, thus, is of value as a research tool.