Metabolism of glucose, fructose and lactate in vivo in chronically cannulated foetuses and in suckling lambs.
Metabolism of glucose, fructose and lactate in vivo in chronically cannulated foetuses and in suckling lambs.
复制标题
长期插管胎儿和哺乳羔羊体内葡萄糖、果糖和乳酸的代谢。
DOI：
10.1042/bj1620617
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
F. Ballard
中科院分区：
文献类型：
--
作者：
D. Warnes;R. Seamark;F. Ballard
1.对长期插管的羊胎和哺乳羔羊注射14C标记的葡萄糖、果糖或乳酸盐，并在最小压力和无麻醉条件下连续采集血样。2.从乳酸葡萄糖异生是没有检测到的胎羊，但该途径是活跃在哺乳羔羊。3.果糖利用率低，胎儿羊，没有可测量的转化为葡萄糖或乳酸。4.在哺乳羔羊中，胎儿中葡萄糖和乳酸不可逆损失的高比率降低。标记葡萄糖的放射性进入胎羊的乳酸盐和果糖池，并进入哺乳羔羊的乳酸盐池。5.提出了一个模型，其中葡萄糖，果糖和乳酸之间的碳流已被量化的胎羊。
1. Chronically cannulated sheep foetuses and suckling lambs were injected with 14C-labelled glucose, fructose or lactate, and sequential blood samples taken under conditions of minimal stress and without anaesthesia. 2. Gluconeogenesis from lactate was not detectable in foetal sheep, but the pathway was active in suckling lambs. 3. Fructose utilization rates were low in foetal sheep, with no measurable conversion into glucose or lactate. 4. The high rates of irreversible loss of both glucose and lactate in the foetus were decreased in suckling lambs. Radioactivity from labelled glucose entered both the lactate and fructose pools in foetal sheep, and entered the lactate pool in suckling lambs. 5. A model is proposed in which carbon flow between glucose, fructose and lactate has been quantified in foetal sheep.