Parallel progression of primary tumours and metastases
Parallel progression of primary tumours and metastases
复制标题
DOI：
10.1038/nrc2627
复制
发表时间：
2009-04-01
影响因子：
78.5
通讯作者：
Klein, Christoph A.
中科院分区：
文献类型：
--
作者：
Klein, Christoph A.
系统性癌症进展在两个基本模型中被解释。流行的原型将癌症进展的引擎置于完全恶性细胞转移性传播之前的原发肿瘤内。第二个假设平行的，独立的进展转移所产生的早期扩散的肿瘤细胞。这一观点汇集了来自病程、肿瘤生长率、尸检研究、临床试验和原发性和播散性肿瘤细胞的分子遗传学分析的数据，以支持平行进展模型。对该模型的考虑促使对当前诊断和治疗常规的回顾。
Systemic cancer progression is accounted for in two basic models. The prevailing archetype places the engine of cancer progression within the primary tumour before metastatic dissemination of fully malignant cells. The second posits parallel, independent progression of metastases arising from early disseminated tumour cells. This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated tumour cells in support of the parallel progression model. consideration of this model urges review of current diagnostic and therapeutic routines.