Efficacy of short‐term dexamethasone therapy in acute‐on‐chronic pre‐liver failure
Efficacy of short‐term dexamethasone therapy in acute‐on‐chronic pre‐liver failure
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DOI：
10.1111/j.1872-034x.2010.00740.x
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发表时间：
2011-01
影响因子：
4.2
通讯作者：
Xu-qing Zhang;Li Jiang;J. You;Yu-Yuan Liu;Jing Peng;Huiyan Zhang;Bao-yan Xu;Q. Mao
中科院分区：
文献类型：
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作者：
Xu-qing Zhang;Li Jiang;J. You;Yu-Yuan Liu;Jing Peng;Huiyan Zhang;Bao-yan Xu;Q. Mao
目的：急性-慢性肝前衰竭是指慢性乙型病毒性肝炎的严重急性发作，其特征是血清胆红素水平达到或超过171umol/L，丙氨酸氨基转移酶达到或超过正常上限的5倍，凝血酶原活性超过40%，有可能发展为急性-慢性肝功能衰竭。本研究旨在评价短期地塞米松治疗急性肝功能衰竭前期的疗效。
Aim: Acute‐on‐chronic pre‐liver failure (pre‐ACLF) is defined as a severe acute episode of chronic hepatitis B characterized by serum bilirubin of 171 µmol/L or more, alanine aminotransferase of five times or more the upper limit of normal and prothrombin activity of more than 40%, having a potential for progression to acute‐on‐chronic liver failure (ACLF). This study is to evaluate the efficacy of short‐term dexamethasone in pre‐ACLF.