Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients
Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients
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DOI：
10.1016/j.jad.2015.05.041
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发表时间：
2015-09-15
影响因子：
6.6
通讯作者：
Azorin, Jean-Michel
中科院分区：
文献类型：
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作者：
Belzeaux, Raoul;Boyer, Laurent;Azorin, Jean-Michel
背景：药物依从性是双相情感障碍的一个主要问题。非计划冲动，定义为缺乏未来的方向，已被证明是主要的冲动领域改变，在心境正常的双相情感障碍患者。方法：研究260例情感正常的双相情感障碍患者的服药依从性和非计划性冲动性之间的关系。采用药物依从性评定量表评价患者的药物依从性，采用Banat冲动量表评价患者的非计划性冲动。采用单因素分析和线性回归分析。我们还进行了路径分析，以检查是否非计划冲动有直接或间接的影响上坚持，介导的comorbidity.Results：坚持药物治疗与非计划冲动，即使在控制潜在的混杂因素的线性回归分析（β标准化系数=0.156，p=0.015）。路径分析表明，只有一个直接的影响，非计划冲动对坚持服药，并没有间接影响，通过物质使用障碍和焦虑disorders.Limitations：我们的研究是有限的，其横截面设计和坚持服药仅通过自我questionnaire.Conclusions：较高的非计划冲动与低服药依从性，通过合并症没有间接影响。(C)2015 Elsevier B.V.版权所有。
Background: Adherence to medication is a major issue in bipolar disorder. Non planning impulsivity, defined as a lack of future orientation, has been demonstrated to be the main impulsivity domain altered during euthymia in bipolar disorder patients. It was associated with comorbidities.Methods: To investigate relationship between adherence to medication and non-planning impulsivity, we included 260 euthymic bipolar patients. Adherence to medication was evaluated by Medication Adherence Rating Scale and non-planning impulsivity by Banat Impulsiveness Scale. Univariate analyses and linear regression were used. We conducted also a path analysis to examine whether non-planning impulsivity had direct or indirect effect On adherence, mediated by comorbidities.Results: Adherence to medication was correlated with non-planning impulsivity, even after controlling for potential confounding factors in linear regression analysis (Beta standardized coefficient=0.156; p=0.015). Path analysis demonstrated only a direct effect of non-planning impulsivity on adherence to medication, and none indirect effect via substance use disorders and anxiety disorders.Limitations: Our study is limited by its cross-sectional design and adherence to medication was assessed only by self-questionnaire.Conclusions: Higher non-planning impulsivity is associated with low medication adherence, without an indirect effect via comorbidities. (C) 2015 Elsevier B.V. All rights reserved.