Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains
Involvement of mouse mammary tumor virus in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains
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小鼠乳腺肿瘤病毒参与低乳腺肿瘤小鼠品系自发性和激素诱导的乳腺肿瘤
DOI：
10.1128/jvi.27.3.551-559.1978
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发表时间：
1978
影响因子：
5.4
通讯作者：
L. Boot
中科院分区：
文献类型：
--
作者：
Rob Michalides;L. Deemter;R. Nusse;G. Ropcke;L. Boot
通过比较小鼠乳腺肿瘤和其他组织中的MTV RNA和MTV DNA序列的数量，研究了小鼠乳腺肿瘤病毒（MTV）在低乳腺肿瘤小鼠品系中自发性和诱导性乳腺肿瘤中的作用。获得了以下结果。(i)与未感染的器官相比，由于MTV感染而出现在C3 H小鼠中的乳腺肿瘤含有更多的MTV DNA;这些乳腺肿瘤也含有更多的MTV RNA。(ii)通过C3 Hf和O20小鼠垂体同系移植物给予过量催乳素的激素刺激导致乳腺中MTV RNA表达增加。然而，这种MTV RNA表达水平的升高在乳腺癌诱导的乳腺肿瘤中没有维持。(iii)BALB/c小鼠的自发性乳腺肿瘤中含有与这些动物的其他细胞中发现的相似水平的MTV DNA和MTV RNA序列。
The involvement of the mouse mammary tumor virus (MTV) in spontaneous and hormone-induced mammary tumors in low-mammary-tumor mouse strains was studied by comparing the amounts of MTV RNA and MTV DNA sequences in mammary tumors and other tissues of mice with an without hormonal treatments. The following results were obtained. (i) Mammary tumors which appeared in C3H mice as a result of an infection with MTV contained more MTV DNA compared with noninfected organs; these mammary tumors also contained more MTV RNA than was present in lactating mammary gland cells. (ii) Hormonal stimulation by administration of excessive amounts of prolactin via hypophyseal isografts in C3Hf and O20 mice resulted in an increased expression of MTV RNA in the mammary glands. This elevated level of MTV RNA expression was, however, not maintained in the hormone-induced mammary tumors. (iii) Spontaneous mammary tumors in BALB/c mice contained similar levels of MTV DNA and MTV RNA sequences as were found in other cells of these animals.