Status of Serum and Salivary Levels of Superoxide Dismutase in Type 2 Diabetes Mellitus with Oral Manifestations: A Case Control Study
Status of Serum and Salivary Levels of Superoxide Dismutase in Type 2 Diabetes Mellitus with Oral Manifestations: A Case Control Study
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DOI：
10.4314/ejhs.v26i6.4
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发表时间：
2016-11-01
影响因子：
1.2
通讯作者：
Bhat, Manohar
中科院分区：
文献类型：
--
作者：
Madi, Medhini;Babu, Subhas;Bhat, Manohar
背景：2型糖尿病是一种众所周知的代谢紊乱，在世界范围内已达到流行的程度。有证据表明，由于活性氧簇的过量产生和抗氧化防御机制受损，糖尿病患者的氧化应激会增加。本研究对45名健康受试者和45名2型糖尿病患者的血清和唾液中的超氧化物歧化酶水平进行了评估，并对这些受试者的血清和唾液中的超氧化物歧化酶水平进行了比较。与健康受试者相比，2型糖尿病口腔表现受试者的平均血清和唾液超氧化物歧化酶水平显著降低。在健康和糖尿病患者的血清和唾液samples.CONCLUSION之间的正相关性观察：这项研究强调，在糖尿病患者的氧化应激水平异常高，再加上同时下降的抗氧化防御机制的结果在糖尿病并发症。因此，探索唾液中准确反映身体氧化还原状态的抗氧化标记物是值得的。
BACKGROUND: Type 2 Diabetes Mellitus is a very well known metabolic disorder that has reached epidemic proportions worldwide. Evidence suggests that oxidative stress increases in Diabetes Mellitus because of the excessive production of reactive oxygen species and an impaired antioxidant defence mechanism. This study estimated, compared and correlated the serum and salivary Superoxide dismutase levels in healthy subjects and subjects with Type 2 Diabetes Mellitus having oral manifestations.MATERIALS AND METHODS: In this study, serum and salivary Superoxide dismutase levels were estimated in 45 healthy subjects and 45 patients with Type 2 Diabetes Mellitus with oral manifestations.RESULTS: The mean serum and salivary Superoxide dismutase levels were significantly decreased in subjects with Type 2 Diabetes Mellitus with oral manifestations compared to the healthy subjects. Positive correlation in both healthy and diabetics was observed between serum and salivary samples.CONCLUSION: This study highlights that the abnormally high levels of oxidative stress in diabetics coupled with simultaneous decline in antioxidant defence mechanism results in complications in Diabetes mellitus. Thus exploring saliva for antioxidant markers that accurately reflect the redox status of the body is worthwhile.