Striatal opiate receptors: pre- and postsynaptic localization.
Striatal opiate receptors: pre- and postsynaptic localization.
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纹状体阿片受体：突触前和突触后定位。
DOI：
10.1016/0024-3205(80)90469-5
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
Kuhar,MJ
中科院分区：
文献类型：
--
作者：
Murrin,LC;Coyle,JT;Kuhar,MJ
大鼠纹状体中阿片受体与特异性结合的 3 H-二丙诺啡的放射自显影定位揭示了相对较小、高密度的受体簇、沿着纹状体-胼胝体边界的高密度受体带以及分布在神经毡其余部分的较低密度的受体。红藻氨酸损伤的放置导致簇中受体损失 94%，其他区域损失较小。通过放置内侧前脑束损伤或通过纹状体内注射 6-羟基多巴胺来去除纹状体中含有多巴胺的输入，导致非簇区域中的受体比簇区域中的受体消耗更大。在重复的生化和放射自显影研究中，在丘脑病变的剥皮或放置后没有发现任何变化。结论是，大部分纹状体阿片受体位于突触后固有纹状体神经元及其突起上，而其余受体大部分位于含有多巴胺的轴突和末端。
Autoradiographic localization of opiate receptors in the rat striatum with specifically bound3H-diprenorphine reveals relatively small, high density clusters of receptors, a high density band of receptors along the striatal-callosal border, and a lower density of receptors spread over the remainder of the neuropil. Placement of kainate lesions resulted in a 94% loss of receptors in the clusters and a smaller loss in other areas. Removal of the dopamine-containing input to the striatum by placement of medial forebrain bundle lesions or by intrastriatal injection of 6-hydroxydopamine resulted in a greater depletion of receptors in the non-cluster areas compared to cluster areas. In repeated biochemical and autoradiographic studies, no change was found after either decortication or placement of thalamic lesions. It is concluded that the bulk of striatal opiate receptors are localized postsynaptically on intrinsic striatal neurons and their processes with the bulk of the remaining receptors localized to the dopamine-containing axons and terminals.