Trigeminal orosensation and ingestive behavior in the rat.
Trigeminal orosensation and ingestive behavior in the rat.
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大鼠的三叉神经口腔感觉和摄入行为。
DOI：
10.1037//0735-7044.97.1.62
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发表时间：
1983
影响因子：
1.9
通讯作者：
Zeigler,HP
中科院分区：
文献类型：
--
作者：
Jacquin,MF;Zeigler,HP
以雄性Wistar大鼠为实验对象，采用去传入的方法研究三叉神经嗅觉在控制进食行为中的作用。该手术去除了口腔的体感输入，同时保留了嗅觉、舌味、触觉输入以及颌肌的本体感觉传入和传出。对照组为带舌或颌肌传出的SS组。双侧三叉神经口感觉神经去传入对进食行为的影响与去传入的程度成正比。三叉神经综合征包括失语和肥胖，进食和饮水的感觉运动控制受损，对食物和水的反应性降低，以及体重调节水平降低。三叉神经的去传入没有基本的进食运动模式(咬、舔和咀嚼)，但被口周刺激扰乱了它们的控制。食物摄入量的不足因饮食的感官特性而异。摄入量的恢复是沿着适口性梯度进行的，而水摄入量的恢复与干食物的恢复是平行的。体重的长期下降是由持续性的低吞食症引起的，反映了对食物的反应性降低。研究结果表明，在调节大鼠感觉运动和摄取动机控制的神经机制中，存在相当程度的重叠。(参考文献76)
Used a deafferentation procedure with male Wistar rats to examine the contributions of trigeminal orosensation to control of ingestive behavior. The procedure removed somatosensory input from the mouth while sparing olfaction, lingual taste, vibrissae inputs, and proprioceptive afferents from and efferents to the jaw muscles. Ss with sections of tongue or jaw muscle efferents served as controls. Bilateral trigeminal orosensory deafferentation was followed by effects on ingestive behavior, the magnitudes of which were proportional to the extent of the deafferentation. The trigeminal syndrome includes aphagia and adipsia, impairments in the sensorimotor control of eating and drinking, decreased responsiveness to food and water, and a reduction in the level of body weight regulation. Trigeminal deafferentation spared elementary ingestive movement patterns (biting, licking, and chewing) but disrupted their control by the perioral stimuli. Deficits in food intake varied with the sensory properties of the diet. Recovery of intake took place along a palatability gradient, and recovery of water intake paralleled that of dry food. The chronically reduced body weight was caused by persistent hypophagia and reflected reduced responsiveness to food. Findings suggest a considerable degree of overlap in the neural mechanisms mediating the sensorimotor and motivational control of intake in the rat.(76 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)