IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
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DOI：
10.1016/s0167-5699(97)01103-1
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发表时间：
1997-09-01
期刊：
影响因子：
--
通讯作者：
Mier, LW
中科院分区：
文献类型：
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作者：
Tilg, H;Dinarello, CA;Mier, LW
急性炎症伴随着急性时相蛋白(APP)浓度的变化。虽然人们对参与炎症启动的细胞因子知之甚多，但对参与炎症消退的介质却知之甚少。最近的研究表明，白介素6(IL-6)和IL-6调节的APP具有抗炎和免疫抑制作用，可能对急性时相反应具有负性调节作用。
Acute inflammation is accompanied by changes in the concentrations of acute phase proteins (APPs). While much is known about the cytokines involved in the initiation of inflammation, less is known about the mediators involved in its resolution. Recent data suggest that interleukin 6 (IL-6) and IL-6-regulated APPs are anti-inflammatory and immunosuppressive, and may negatively regulate the acute phase response.