Procalcitonin is More Useful Than C-reactive Protein in Differentiation of Fever in Patients With Sickle Cell Disease
Procalcitonin is More Useful Than C-reactive Protein in Differentiation of Fever in Patients With Sickle Cell Disease
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降钙素原比 C 反应蛋白更有助于区分镰状细胞病患者的发热
DOI：
10.1097/mph.0b013e3182495573
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
S. Erdoğan
中科院分区：
文献类型：
--
作者：
S. Unal;A. Arslankoylu;N. Kuyucu;G. Aslan;S. Erdoğan
本研究旨在评价C反应蛋白（CRP）和降钙素原（PCT）水平在镰状细胞病（SCD）发热鉴别诊断中的价值。该研究包括86名SCD儿童（组1）和49名对照组（组2）。在研究期间，患者有114次急性发作或常规访问单位。他们被分为有发热的血管闭塞危象（1A组），无发热的血管闭塞危象（1B组），和无危象或发热（稳态，1C组）。只有危急的病人才被送进医院。每次入院时出现各种临床体征和症状的患者被纳入1A、1B和1C组。因此，共分析了114例临床事件。3个患者组的平均CRP水平均显著高于第2组，且在患者组中，第1A组的平均CRP水平显著高于其他组。1A、1B组CRP水平明显高于1C组。3个SCD组之间的中位血清PCT水平无显著差异;但是，1A组、1B组和1C组患者的中位PCT水平显著高于第2组患者。这些数据表明，血管闭塞性疾病伴或不伴发热与SCD儿童的基线状态相比，PCT水平明显升高，而SCD儿童的基线状态明显高于对照儿童的PCT水平。
This study aimed at evaluating the value of C-reactive protein (CRP) and procalcitonin (PCT) levels in the differential diagnosis of fever in patients with sickle cell disease (SCD). The study included 86 children with SCD (group 1) and 49 controls (group 2). During the study, the patients had 114 acute episodes or routine visits to the units. They were classified as having vasoocclusive crisis with fever (group 1A), vasoocclusive crisis without fever (group 1B), and no crisis or fever (steady state, group 1C). Only patients with crises were admitted to the hospital. Patients admitted to the hospital with various clinical signs and symptoms each and every time were included in groups 1A, 1B, and 1C. Thus, a total of 114 clinical episodes were analyzed. The mean CRP levels in the 3 patient groups were significantly higher than that in the group 2, and among the patient groups, the mean CRP was significantly higher in group 1A than the other groups. The mean CRP level in group 1A and group 1B was significantly higher than that in group 1C. There were no significant differences among the 3 SCD groups in terms of the median serum PCT level; however, the median PCT level in group 1A, group 1B, and group 1C patients was significantly higher than that in group 2 patients. These data indicate that vasoocclusive disease with or without fever apparently does not significantly increase PCT levels in relation to the baseline status of children with SCD, which in turn are clearly more elevated than PCT levels of control children.
影响因子：
20.3
作者：
Solovey, AA;Solovey, AN;Hebbel, RP
通讯作者：
Hebbel, RP