Encapsulation of lemongrass oil with cyclodextrins by spray drying and its controlled release characteristics
Encapsulation of lemongrass oil with cyclodextrins by spray drying and its controlled release characteristics
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DOI：
10.1080/09168451.2016.1277942
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发表时间：
2017-04-01
影响因子：
1.6
通讯作者：
Soottitantawat, Apinan
中科院分区：
文献类型：
--
作者：
Phunpee, Sarunya;Ruktanonchai, Uracha Rangsadthong;Soottitantawat, Apinan
在各种环糊精（-CD、-CD 和 -CD）主体分子的范围内研究了柠檬草油成分柠檬醛的两种异构体（E-柠檬醛和 Z-柠檬醛）的内含物。 E-柠檬醛与-CD、-CD和-CD的水性复合物形成常数分别测定为123、185和204 L/mol，而Z-柠檬醛表现出更强的亲和力（分别为157、206和253 L/mol）。结合趋势-CD>-CD>-CD反映了随着空腔尺寸的增加，柠檬醛异构体的更有利的几何适应。通过摇动柠檬醛：CD（摩尔比为 1:1、1.5:1 和 2:1）混合物，然后喷雾干燥，将柠檬草油封装在 CD 中。最大柠檬醛保留发生在 1:1 摩尔比时，-CD 和 -CD 分别表现出最高水平的总 E-柠檬醛和 Z-柠檬醛保留。此外，-CD 复合物显示出所有包合复合物粉末中释放速率最慢的。
Inclusion of the two isomers of citral (E-citral and Z-citral), components of lemongrass oil, was investigated within the confines of various cyclodextrin (-CD, -CD and -CD) host molecules. Aqueous complex formation constants for E-citral with -CD, -CD and -CD were determined to be 123, 185, and 204 L/mol, respectively, whereas Z-citral exhibited stronger affinities (157, 206, and 253 L/mol, respectively). The binding trend -CD>-CD>-CD is a reflection of the more favorable geometrical accommodation of the citral isomers with increasing cavity size. Encapsulation of lemongrass oil within CDs was undertaken through shaking citral:CD (1:1, 1.5:1, and 2:1 molar ratio) mixtures followed by spray drying. Maximum citral retention occurred at a 1:1 molar ratio with -CD and -CD demonstrating the highest levels of total E-citral and Z-citral retention, respectively. Furthermore, the -CD complex demonstrated the slowest release rate of all inclusion complex powders.