Growth and morphological changes in the small and the large intestine in piglets during the first three days after birth.
Growth and morphological changes in the small and the large intestine in piglets during the first three days after birth.
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发表时间：
1992-10
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通讯作者：
R. Xu;D. Mellor;P. Tungthanathanich;M. Birtles;G. Reynolds;H. Simpson
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作者：
R. Xu;D. Mellor;P. Tungthanathanich;M. Birtles;G. Reynolds;H. Simpson
在仔猪出生后的前三天内检查小肠和大肠的生长和形态变化。小肠重量增加了 72%，几乎所有这些都发生在第一天，主要是由于粘膜重量增加了 115%。第一天期间，与组织重量增加相关的是，小肠长度增加24%，小肠直径增加15%，绒毛高度增加33-90%，绒毛直径增加14-51%。小肠粘膜中的细胞数量，如DNA含量所示，随着年龄的增长而逐渐增加，三天时增加了84-154%。十二指肠粘膜 DNA 含量增加百分比最高，空肠居中，回肠最低。组织学特征和组织蛋白质含量显示，第一天出现与细胞内蛋白质积累相关的短暂上皮细胞肿胀。空肠和回肠中蛋白质积累明显，但十二指肠中不明显。上皮细胞中细胞核的位置表明，第一天，空肠和近端回肠中的蛋白质吸收比远端回肠中处于更先进的阶段。第一天大肠重量增加了 33%，第三天增加了一倍，这种重量增加是由于粘膜和非粘膜组织的生长所致。在仔猪出生时和出生后一天的盲肠和近端结肠中观察到绒毛样结构，但在出生后三天的仔猪中没有观察到绒毛样结构。据推测，这种绒毛状结构在新生儿完全依赖口服营养的过渡过程中可能具有功能意义。
Growth and morphological changes in the small and the large intestine of piglets were examined during the first three days after birth. There was a 72% increase in small intestinal weight, virtually all of which occurred during the first day and was due primarily to a 115% increase in the weight of the mucosa. Associated with the tissue weight gain there was a 24% increase in small intestinal length, a 15% increase in small intestinal diameter, a 33-90% increase in villus height and a 14-51% increase in villus diameter, during the first day. The cellular population in the small intestinal mucosa, as indicated by its DNA content, increased progressively with age, and at three days had increased by 84-154%. The percentage increase in mucosal DNA content was highest in the duodenum, intermediate in the jejunum and lowest in the ileum. Histological features and tissue protein contents revealed a transient epithelial cellular swelling related to intracellular accumulation of protein on the first day. Protein accumulation was evident in the jejunum and ileum but not in the duodenum. The positions of the nuclei in the epithelial cells suggested that on the first day protein absorption was at a more advanced stage in the jejunum and the proximal ileum than in the distal ileum. Large intestinal weight increased by 33% during the first day and had doubled by the third day, and this weight gain was due to both mucosal and non-mucosal tissue growth. Villus-like structures were observed in the caecum and the proximal colon in piglets at birth and one day after birth but not in piglets three days after birth. It is speculated that such villus-like structures may have a functional significance during the transition to complete dependence on oral nutrition in newborns.