Mood disorders are highly prevalent in patients investigated with a multiple sleep latency test
Mood disorders are highly prevalent in patients investigated with a multiple sleep latency test
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DOI：
10.1007/s11325-017-1572-8
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发表时间：
2018-05-01
影响因子：
2.5
通讯作者：
Dabscheck, Eli
中科院分区：
文献类型：
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作者：
Denton, Eve J.;Barnes, Maree;Dabscheck, Eli
C 目的 白天过度嗜睡 (EDS) 是一种使人衰弱的症状，常见于原发性睡眠障碍和情绪障碍。通过平均睡眠潜伏期测试（MSLT）客观评估 EDS 患者情绪障碍的患病率尚未有报道。我们假设情绪障碍在接受 EDS 检查的患者中非常普遍。本研究旨在报告 MSLT 人群中情绪障碍的患病率，并调查情绪障碍与客观和主观嗜睡评分之间的关联。方法对患有 MSLT 的成年人进行回顾性多中心研究，并在 3 年时间内确定医院焦虑和抑郁评分 (HADS)。 HADS 是一份经过验证的问卷，用于检测睡眠诊所人群的抑郁 (HADS-D >= 8) 和焦虑 (HADS-A >= 11)。收集的数据包括人口统计、医疗和睡眠研究信息。将情绪障碍患病率与一般睡眠诊所人群进行比较。进行了睡意和情绪测量之间的相关性。结果 220 名患者平均年龄 41.1 +/- 15.7 岁，平均体重指数 28.6 kg/m(2)，其中 30% 患有焦虑症 (HADS-A > 11)，43% 患有抑郁症 (HADS-D > 8)。该队列的平均结果为 ESS 13.7、平均睡眠潜伏期 11.5 分钟、HADS-A 8.2 和 HADS-D 7。通过平均睡眠潜伏期测量的客观嗜睡与 HADS-A（-0.006，p = 0.93）或 HADS-D 评分（0.002，p = 0.98）之间没有显着相关性。然而，ESS 测量的主观困倦与平均睡眠潜伏期 (-0.25，p < 0.01)、HADS-A (0.15，p = 0.03) 和 HADS-D (0.2，p = 0.004) 之间存在微弱相关性。睡眠过度障碍的诊断与焦虑 (p = 0.71) 或抑郁 (p = 0.83) 之间没有显着关联。 结论 情绪障碍在 MSLT 人群中非常普遍。嗜睡和情绪障碍的主观测量之间存在弱相关性，但嗜睡和情绪障碍的客观测量之间没有相关性。应考虑对嗜睡患者进行情绪障碍的常规筛查。
C Purpose Excessive daytime sleepiness (EDS) is a debilitating symptom which occurs commonly in both primary sleep and mood disorders. The prevalence of mood disorders in patients with EDS, evaluated objectively with a mean sleep latency test (MSLT), has not been reported. We hypothesize that mood disorders are highly prevalent in patients being investigated for EDS. This study aims to report the prevalence of mood disorder in the MSLT population and investigate the association between mood disorder and objective and subjective scores of sleepiness.Methods A retrospective multicenter study of adults with a MSLT and Hospital Anxiety and Depression Score (HADS) identified over a 3-year period. The HADS is a validated questionnaire in detecting depression (HADS-D >= 8) and anxiety (HADS-A >= 11) in the sleep clinic population. Data collected included demographics, medical, and sleep study information. Mood disorder prevalence was compared to the general sleep clinic population. Correlation between measures of sleepiness and mood was performed.Results Two hundred twenty patients were included with mean age 41.1 +/- 15.7 years, mean body mass index 28.6 kg/m(2) of whom 30% had anxiety (HADS-A > 11) and 43% depression (HADS-D > 8). Mean results for the cohort are ESS 13.7, mean sleep latency 11.5 min, HADS-A 8.2, and HADS-D 7. There was no significant correlation between objective sleepiness, as measured by the mean sleep latency, and either HADS-A (-0.006, p = 0.93) or HADS-D score (0.002, p = 0.98). There was, however, a weak correlation between subjective sleepiness, as measured by the ESS, and the mean sleep latency (-0.25, p < 0.01), HADS-A (0.15, p = 0.03), and HADS-D (0.2, p = 0.004). There was no significant association between diagnosis of hypersomnia disorders and presence of anxiety (p = 0.71) or depression (p = 0.83).Conclusions Mood disorders are highly prevalent in the MSLT population. There was a weak correlation found between subjective measures of sleepiness and mood disorders, but not between objective measures of sleepiness and mood disorders. Routine screening for mood disorders in patients with hypersomnolence should be considered.