Histology of Kashin-Beck lesions
Histology of Kashin-Beck lesions
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DOI：
10.1007/s002640000190
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发表时间：
2001-06-01
影响因子：
2.7
通讯作者：
Perlmutter, N
中科院分区：
文献类型：
--
作者：
Pasteels, JL;Liu, FD;Perlmutter, N
现存的描述大骨节病组织病理学的论文很少。目前已有的少数文献中提到了骨骺原基和干骺端软骨内的软骨坏死。在目前的研究中，有两个系列的样本可用于组织学：从年轻受试者身上取出多余的手指，以及在更晚期的疾病病例中收集关节内小体。这些标本的主要特征是指骨近端软骨终板内没有血管形成，与骨骺骨形成的改变有关。这些观察结果表明，大骨节病的发生可能源于干骨干端软骨血管生成的改变，导致退行性变并导致关节发育不良，这可能与干骨干端骨骼的生长减少有关。
There are few papers in existence describing the histopathology of Kashin-Beck disease. The few existing papers mention chondronecrosis within the epiphyseal primodium and metaphyseal cartilage. In the present study, two series of samples were available for histology: supernumerary fingers removed from young subjects and intra-articular bodies collected in more advanced cases of the disease. The prevailing characteristic of the samples is the absence of vascularisation within the proximal cartilage end plate of the phalanx associated with an alteration of the epiphyseal bone formation. These observations suggest that Kashin-Beck disease could develop from an alteration of the angiogenesis of the metaphyseal cartilage resulting in degeneration with consequent joint dysplasia, which may be associated with a decrease in growth of the diaphyseal bones.