Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells.
复制标题
白介素（IL）-15和IL-7联合调节记忆表型CD8+细胞的体内稳态增殖，但对于记忆表型CD4+细胞不需要。
DOI：
10.1084/jem.20020066
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发表时间：
2002-06-17
影响因子：
15.3
通讯作者：
Surh, Charles D
中科院分区：
文献类型：
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作者：
Tan, Joyce T;Ernst, Bettina;Kieper, William C;LeRoy, Eric;Sprent, Jonathan;Surh, Charles D
初始和记忆T细胞池的总体大小和组成受到稳态机制的严格调节。最近的研究表明，幼稚T细胞的稳态是由两个因素，自身主要组织相容性复合体（MHC）/肽配体和细胞因子，白细胞介素（IL）-7控制。特别地，幼稚CD 4+和CD 8+细胞需要与这两种因子接触以进行“稳态”增殖，即，由于严重的T细胞耗竭而诱导的增殖。与初始T细胞相比，驱动记忆T细胞进行稳态增殖的因素知之甚少。为了解决这个问题，从正常小鼠中纯化的记忆表型CD 4+和CD 8+细胞过继转移到各种基因敲除小鼠中，通过亚致死辐射使T细胞缺陷。报告了三项调查结果。首先，与初始T细胞不同，记忆T细胞的稳态增殖在很大程度上不依赖于MHC。第二，记忆CD 8+细胞可以利用IL-7或IL-15进行稳态增殖;然而，在缺乏IL-7和IL-15的情况下，稳态增殖不能发生。第三，与记忆性CD 8+细胞不同，记忆性CD 4+细胞的稳态增殖不依赖于IL-7和IL-15（也是IL-4）。因此，控制记忆性CD 8+细胞和记忆性CD 4+细胞的稳态增殖机制是相当不同的。
The overall size and composition of the pool of naive and memory T cells are tightly regulated by homeostatic mechanisms. Recent work has shown that homeostasis of naive T cells is controlled by two factors, self-major histocompatibility complex (MHC)/peptide ligands and a cytokine, interleukin (IL)-7. In particular, contact with these two factors is required for naive CD4+ and CD8+ cells to undergo “homeostatic” proliferation, i.e., proliferation induced as a consequence of severe T cell depletion. In contrast to naive T cells, the factors that drive memory T cells to undergo homeostatic proliferation are poorly understood. To address this issue, purified memory phenotype CD4+ and CD8+ cells from normal mice were adoptively transferred into various gene-knockout mice rendered T cell–deficient by sublethal irradiation. Three findings are reported. First, unlike naive T cells, homeostatic proliferation of memory T cells is largely MHC independent. Second, memory CD8+ cells can utilize either IL-7 or IL-15 to undergo homeostatic proliferation; however, in the absence of both IL-7 and IL-15, homeostatic proliferation fails to occur. Third, unlike memory CD8+ cells, homeostatic proliferation of memory CD4+ cells is independent of IL-7 and IL-15 (also IL-4). Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct.