Oncological diagnosis using 11C-choline-positron emission tomography in comparison with 2-deoxy 2-[18F]fluoro-D-glucose-positron emission tomography
Oncological diagnosis using 11C-choline-positron emission tomography in comparison with 2-deoxy 2-[18F]fluoro-D-glucose-positron emission tomography
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DOI：
10.1016/j.mibio.2004.02.003
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Endo, K
中科院分区：
文献类型：
--
作者：
Tian, M;Zhang, H;Endo, K
目得：评估和比较C-11-胆碱-正电子发射断层扫描（PET）和2-脱氧-2-[ F-18]氟-D-葡萄糖（FDG）-PET在各种肿瘤良恶性鉴别中的作用。材料和方法：我们检查了38例连续的各种肿瘤患者，包括7例脑肿瘤，2例口腔肿瘤，2例食管癌，肺癌6人，骨肿瘤11人，软组织肿瘤9人，骨髓瘤1人。分别在注射275-455 MBq示踪剂后5分钟和40分钟进行C-11-Choline-PET和FDG-PET。结果：24例恶性肿瘤的C 11-胆碱摄取率（3.9 ± 1.7，n = 24）明显高于14例良性病变（1.7 ± 1.2，n = 14）（P < 0.0001）。另一方面，恶性肿瘤的FDG摄取为4.9 ± 2.0（n = 24），也显著大于良性病变的1.6 ± 1.3（n = 14）（P < 0.0001）。所有病灶的C-11-Choline摄取与FDG摄取呈正相关（r = 0.658，P < 0.02，n = 38）。受试者工作特征（ROC）分析显示，C-11-Choline-PET的ROC曲线下面积为0.871，与FDGPET的ROC曲线下面积0.929比较，差异无统计学意义。结论：C-11-Choline-PET与FDGPET在鉴别各种肿瘤良恶性方面具有相似性。2004年爱思唯尔公司All rights reserved.
PURPOSE: To assess and compare the usefulness of C-11-Choline-positron emission tomography (PET) with that of 2-deoxy-2-[ F-18] fluoro-D-glucose (FDG)-PET for the differentiation between benign and malignant in various tumors.MATERIALS AND METHODS: We examined 38 consecutive patients with various tumors, including seven patients with brain tumors, two with oral cavity tumor, two with esophageal cancer, six with lung cancer, 11 with bone tumor, nine with soft tissue tumors, and one with myeloma. C-11-Choline-PET and FDG-PET were performed from five minutes and 40 minutes, respectively, after injection of 275-455 MBq tracer. Tracer uptakes were evaluated by the standardized uptake value (SUV) and were analyzed in according to the pathologic data.RESULTS: C-11-Choline uptake in malignancies (3.9 +/- 1.7, n = 24) was significantly higher than that in benign lesions (1.7 +/- 1.2, n = 14) (P < 0.0001). On the other hand, the FDG uptake in malignancies was 4.9 +/- 2.0 (n = 24) and was also significantly larger than that in benign lesions 1.6 +/- 1.3 (n = 14) (P < 0.0001). The C-11-Choline uptake in all the lesions correlated with FDG uptake (r = 0.658, P < 0.02, n = 38). According to the receiver operating characteristic (ROC) analysis, the area under the ROC curve for C-11-Choline-PET was 0.871, and with no significant difference compared to FDGPET with the area of 0.929.CONCLUSIONS: This study demonstrated that C-11-Choline-PET is similar to FDG-PET in differentiation between malignant and benign lesion in various tumors. 2004 Elsevier Inc. All rights reserved.